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Updated: May 2, 2026

Dual-mode Imaging of Cutaneous Tissue Oxygenation and Vascular Function
Published on: December 8, 2010
Fluorescein Angiogram Causing Cutaneous Venous Staining: A Rare Self-Resolving Phenomenon.
Zachary George Angus1,2, Daini Ong1, Sanjeewa S Wickremasinghe1
1Department of Ophthalmology, Royal Victorian Eye and Ear Hospital, Melbourne, VIC, Australia.
Cutaneous fluorescein staining along arm veins is a rare side effect of fluorescein angiography (FA). This temporary staining, observed in two patients, resolved naturally without intervention.
Area of Science:
- Ophthalmology
- Medical Imaging
Background:
- Fluorescein angiography (FA) is a key diagnostic tool for retinal and choroidal diseases.
- While generally safe, FA can cause mild adverse effects.
- Cutaneous venous staining is a rarely reported complication of FA.
Observation:
- Two cases of cutaneous fluorescein staining following FA are presented.
- Case 1: A 90-year-old female with AMD experienced staining ascending forearm veins.
- Case 2: A 50-year-old male with diabetic macular edema experienced staining descending forearm veins.
Findings:
- Both patients developed temporary staining of superficial forearm veins post-FA.
- The staining was localized around the venous access site.
- The condition was self-limiting and resolved within days.
Implications:
- Cutaneous fluorescein staining is a rare but benign adverse event.
- Conservative management is sufficient for this complication.
- Awareness of this rare side effect is important for clinicians performing FA.
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