[Immunologic reactivity in the rabbit after the application of Xenoderm]

F T Keller, U Falk, D Löbel

Zeitschrift Fur Experimentelle Chirurgie, Transplantation, Und Kunstliche Organe : Organ Der Sektion Experimentelle Chirurgie Der Gesellschaft Fur Chirurgie Der DDR

|January 1, 1985

Abstract

Unlabelled:

The immunological compatibility of the pig skin preparation, Xenoderm was tested in an animal model. Firstly an experimental conception was selected which seized the immune degree of Xenoderm on the humoral and cellular level in animal test. Specific immune reactions should be provoked in rabbit after a repeated artificial immunisation by soluble protein extracts respectively by means of recured implantation of Xenoderm tissue pieces and native pig skin. Test period 3-6 months.

Results:

Native pig skin of the offered configuration induced an intensive humoral and cellular immune reaction in experimental animal. Xenoderm was immunologically inert after application as a soluble protein extract in different concentrations and also as an implant. Xenoderm (desantigenic splitted pig skin preserve) is suitable as a temporary skin replacement for the therapy of skin defects.

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Unlabelled:

Results:

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