Triglyceride glucose index is a risk factor for heart failure: A prospective cohort study
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Published on: January 7, 2018
Yuan Jia1, Yue Zhang1, Shiru Bai1
1Department of Cardiology, Hebei General Hospital, Shijiazhuang, China.
Insights
The triglyceride glucose (TyG) index is linked to a higher risk of death in heart failure (HF) patients. This association is particularly strong in older and female individuals, highlighting the TyG index as a significant predictor of mortality in HF.
Area of Science:
- Cardiology
- Metabolic Syndrome
- Clinical Research
Background:
- Heart failure (HF) is a major cause of mortality worldwide.
- Identifying reliable prognostic markers for HF patients is crucial for risk stratification and management.
- The triglyceride glucose (TyG) index, a marker of insulin resistance, has emerged as a potential prognostic indicator in various cardiovascular conditions.
Purpose of the Study:
- To investigate the association between the triglyceride glucose (TyG) index and all-cause mortality in hospitalized patients diagnosed with heart failure (HF).
- To explore potential differences in this association across various demographic subgroups.
Main Methods:
- A cohort of 1274 hospitalized heart failure (HF) patients was analyzed.
- Patients were stratified into four groups based on quartiles of the triglyceride glucose (TyG) index.
- Multivariate-adjusted Cox proportional hazard models and restricted cubic spline analysis were employed to assess the relationship between TyG index and all-cause mortality over a median follow-up of 1079 days.
Main Results:
- A significant positive correlation was observed between higher triglyceride glucose (TyG) index levels and an increased risk of all-cause mortality in HF patients.
- After complete adjustment, patients in the highest TyG index quartile had a 1.6-fold higher risk of death (HR: 1.6, 95% CI: 1.22-2.09).
- Subgroup analyses revealed a significant association between the TyG index and all-cause mortality in female (HR: 1.31) and older (HR: 1.25) patient groups.
Conclusions:
- The triglyceride glucose (TyG) index is a significant independent predictor of all-cause mortality in hospitalized patients with heart failure (HF).
- The TyG index demonstrates a stronger association with mortality in older and female HF patients, suggesting its utility in risk stratification for these specific populations.
Aims:
This study aimed to investigate the relationship between the triglyceride glucose (TyG) index and all-cause mortality in patients with heart failure (HF).
Methods And Results:
A total of 1274 patients with HF diagnosed at Hebei General Hospital were enrolled in this study. The patients were divided into four groups by quartiles based on the TyG index. The endpoint was all-cause mortality during the follow-up period. The median follow-up period was 1079 days, with a total of 543 (42.7%) patients experiencing all-cause mortality. The survival curves showed no significant difference in endpoint events among the four groups (log-rank P = 0.329). The adjusted survival curves revealed that after adjusting for the variables in Model 3, the group with a higher TyG index exhibited a higher risk of death (log-rank P < 0.001). The multivariate-adjusted Cox proportional hazard models revealed a positive correlation between the TyG index and all-cause mortality. After complete adjustment, patients with the highest TyG index exhibited a higher risk of all-cause mortality than those in the lowest quartile [hazard ratio (HR) = 1.6, 95% confidence interval (CI): 1.22-2.09; P = 0.001]. Restricted cubic spline analysis showed that the risk of all-cause mortality increased linearly with the TyG index (P for non-linear = 0.207). Exploratory subgroup analyses revealed that, as a continuous variable, the TyG index was significantly associated with all-cause mortality in female patients (HR = 1.31, 95% CI: 1.08-1.58, P = 0.029) and older patients (HR = 1.25, 95% CI: 1.1-1.43, P = 0.027).
Conclusions:
The TyG index was positively associated with increased all-cause mortality in hospitalized patients with HF. Subgroup analyses indicated that the TyG index was strongly associated with all-cause mortality in older and female patients.
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