Current treatment paradigms for triple-negative breast cancer

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Updated: Jun 20, 2025

Studying Triple Negative Breast Cancer Using Orthotopic Breast Cancer Model
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Studying Triple Negative Breast Cancer Using Orthotopic Breast Cancer Model

Published on: March 20, 2020

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Sumeet K Yadav1, Roberto A Leon-Ferre2

  • 1Department of Hospital Internal Medicine, Mayo Clinic Health System, Mankato, MN, USA - yadav.sumeet@mayo.edu.

Minerva Medica
|July 17, 2024
PubMed

Insights

Triple negative breast cancer (TNBC) is aggressive and diverse. Novel therapies like immunotherapy and PARP inhibitors are improving outcomes for TNBC patients.

Area of Science:

  • Oncology
  • Medical Research

Background:

  • Triple negative breast cancer (TNBC) comprises 15% of all breast cancers.
  • TNBC is known for its aggressive nature, heterogeneity, and poorer prognosis.

Purpose of the Study:

  • To offer a comprehensive overview of current systemic therapies for TNBC.
  • To introduce novel treatments recently incorporated into TNBC management.

Main Methods:

  • Review of current scientific literature and clinical trial data.
  • Synthesis of information on established and emerging TNBC treatment modalities.

Main Results:

  • Advancements in understanding TNBC biology have identified new molecular targets.
  • Immunotherapy, PARP inhibitors, and antibody-drug conjugates show improved clinical outcomes.

Conclusions:

  • New therapeutic strategies are enhancing treatment options for TNBC.
  • Internal medicine specialists and primary care providers need awareness of these evolving treatments.

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