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Pd-Catalyzed Regioselective Hydrocarboxylation of Alkyl Terminal Olefins with Oxalic Acid
Wenlong Ren1, Xujian Sheng1, Yian Shi1
1Jiangsu Key Laboratory of Advanced Catalytic Materials & Technology, School of Petrochemical Engineering Institute of Natural and Synthetic Organic Chemistry, Changzhou University, Changzhou 213164, China.
Abstract:
A Pd-catalyzed regioselective hydrocarboxylation of alkyl terminal olefins with oxalic acid is described. A wide variety of linear carboxylic acids can be readily obtained in good yields and high l/b (linear/branched) ratios with Pd2(dba)3 and (p-ClPh)3P under mild conditions. The reaction process is operationally simple and requires no handling of toxic CO. In addition, branched carboxylic acids can also be formed in good regioselectivities with PdCl2 and (2',6'-dimethoxy-[1,1'-biphenyl]-2-yl)diphenylphosphine (L1).
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