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Circulating Activated Platelets in Children With Long COVID: A Case-Controlled Preliminary Observation
Danilo Buonsenso1,2, Silvia Sorrentino3, Antonietta Ferretti3
1From the Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
Abstract:
We investigated if children with Long COVID (n=14) have activated platelets compared with healthy controls (n=14). Platelet activation and secretion markers were investigated by flow cytometry using MoAbs directed against P-selectin, CD63, and PAC-1 in quiescent platelets and in platelets stimulated with 10-µM adenosine diphosphate and 25-µM protease activated receptor 1-activating peptide. Circulating platelets of patients with Long COVID had significantly increased expression of the activation marker cytometry using MoAbs directed against P-selectin ( P = 0.019).
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