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Related Experiment Video

Updated: May 7, 2026

Catheterization of the Carotid Artery and Jugular Vein to Perform Hemodynamic Measures, Infusions and Blood Sampling in a Conscious Rat Model

Catheterization of the Carotid Artery and Jugular Vein to Perform Hemodynamic Measures, Infusions and Blood Sampling in a Conscious Rat Model

Published on: January 30, 2015

Carotid web catheter angiography hemodynamic parameters.

Mateus Damiani Monteiro^1,2, Mohamed A Tarek^1,2, Pedro N Martins^1,2

¹Department of Neurology, Emory University School of Medicine, Atlanta, Georgia, USA.

Journal of Neurointerventional Surgery

|July 17, 2024

Summary

Contrast stagnation on digital subtraction angiography (DSA) in patients with carotid web (CaW) did not correlate with anatomical CaW features or clinical presentation. This suggests contrast stagnation time may not accurately reflect the hemodynamic disruption and thrombotic risk associated with carotid webs.

Keywords:

Angiography Stroke

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Published on: February 10, 2023

Area of Science:

Vascular imaging and hemodynamics
Cerebrovascular diseases
Interventional neuroradiology

Background:

Carotid web (CaW) is a rare congenital anomaly that can lead to stroke.
Contrast stagnation observed on digital subtraction angiography (DSA) in CaW is hypothesized to be a marker of stasis, thrombosis, and embolization.
Understanding the relationship between DSA-derived hemodynamic parameters and CaW morphology is crucial for risk stratification.

Purpose of the Study:

To assess the correlation between DSA-derived hemodynamic parameters, specifically contrast stagnation time.
To evaluate the association of contrast stagnation with CT angiography (CTA) structural measurements of the CaW.
To determine the relationship between contrast stagnation and clinical characteristics of patients with CaW.

Main Methods:

Cross-sectional analysis of 60 patients with CaW who underwent both CTA and DSA.
DSA-derived hemodynamic parameters were calculated using time-density curves (TDC) at the carotid bulb.
Mixed effects models were used to evaluate correlations between stagnation time, CaW structural features, and clinical data.

Main Results:

Sixty patients (mean age 52.2 years, 63.3% women, 85% Black) with symptomatic CaW were analyzed.
The median contrast stagnation time was 2.91 seconds.
No significant associations were found between stagnation time and CaW structural measurements (e.g., base, length, thickness, angles, pocket area/perimeter) or clinical characteristics.

Conclusions:

A negative exponential pattern was observed in DSA contrast clearance within the CaW pocket.
Morphological or clinical features did not correlate with the duration of contrast stagnation on DSA.
Contrast stagnation time may not be a reliable indicator of the hemodynamic disruption and thrombotic risk posed by carotid webs.