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Wound infection in elective biliary surgery: controlled trial using one dose cephamandole
The Australian and New Zealand Journal of Surgery
|February 1, 1985
Summary
Prophylactic cephamandole (a cephalosporin antibiotic) significantly reduced wound infection rates in patients undergoing gallbladder stone surgery compared to placebo. This antibiotic also shortened hospital stays, highlighting its clinical benefit in preventing surgical site infections.
Area of Science:
- Surgical Infection Prevention
- Antibiotic Prophylaxis
- Cholelithiasis Management
Background:
- Surgical site infections (SSIs) are a significant complication after cholelithiasis surgery.
- Contaminated bile is a known risk factor for developing SSIs.
- Effective prophylactic antibiotic strategies are crucial for improving patient outcomes.
Purpose of the Study:
- To evaluate the efficacy of single-dose cephamandole prophylaxis in reducing wound infection rates.
- To compare the incidence of wound infections between cephamandole and placebo groups.
- To assess the impact of wound infection on hospital stay duration.
Main Methods:
- Prospective randomized double-blind trial.
- 200 consecutive patients undergoing elective gallbladder stone surgery.
- Single 1g dose of cephamandole or placebo administered 1 hour pre-operatively.
Main Results:
- Overall wound infection rate was 11% (15% placebo vs. 7% cephamandole; P<0.05).
- Average hospital stay was 7.7 days without infection and 13.6 days with infection.
- Cephamandole significantly protected culture-positive patients from wound infection.
Conclusions:
- Single-dose pre-operative cephamandole is effective in preventing wound infections after gallbladder stone surgery.
- Reducing wound infections can lead to shorter hospitalizations.
- Cephamandole offers significant protection, especially in cases with contaminated bile.