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Perspectives on endoscopic functional photoacoustic microscopy.

Shuo Yang¹, Song Hu¹

¹Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, Missouri 63130, USA.

Applied Physics Letters

|July 18, 2024

Summary

Photoacoustic microscopy (PAM) offers high-resolution functional imaging for endoscopy. This perspective explores advancements, challenges, and future directions for endoscopic PAM in biomedical research and clinical applications.

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Area of Science:

Biomedical Optics
Medical Imaging
Endoscopic Technologies

Background:

Endoscopy provides high-resolution imaging crucial for research and clinical practice.
Photoacoustic microscopy (PAM) excels in high-resolution functional imaging.
Integrating PAM into endoscopy presents unique technical challenges.

Purpose of the Study:

To review the progress of endoscopic PAM.
To identify challenges in functional endoscopic PAM.
To outline future directions and opportunities for functional endoscopic PAM.

Main Methods:

Discussion of current advancements in endoscopic PAM development.
Analysis of challenges in achieving functional measurements within endoscopic settings.
Exploration of enabling technologies: fiber optics, microfabrication, optical engineering, and computational methods.

Main Results:

Significant interest exists in combining PAM's functional imaging with endoscopy.
Key challenges remain in implementing functional PAM in endoscopic procedures.
Potential solutions involve integrating advanced optical and computational techniques.

Conclusions:

Endoscopic PAM holds promise for advanced biomedical imaging.
Overcoming current challenges will unlock new diagnostic and research capabilities.
Future developments are expected to drive innovation in translational biomedicine.