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Multidisciplinary Consensus for Rationalizing the Use of Acid Suppressants in Children and Adults: CONFOR
Ram Y Prabhoo1, Uday A Pai2, Arun Wadhwa3
1Department of Orthopedics, Mukund Hospital, Mumbai, Maharashtra, India.
Euroasian Journal of Hepato-Gastroenterology
|July 18, 2024
Summary
This study provides expert consensus on rational acid suppressant use, offering guidelines for appropriate prescribing and deprescribing proton pump inhibitors (PPIs) to improve patient safety and reduce costs.
Area of Science:
- Gastroenterology
- Pharmacology
- Evidence-based Medicine
Background:
- Acid suppression therapy (AST) is widely used for acid peptic disorders.
- Proton pump inhibitors (PPIs) and histamine type 2-receptor antagonists (H2RAs) are common ASTs.
- Concerns exist regarding inappropriate PPI use and adverse effects in children and adults.
Purpose of the Study:
- To establish best practice consensus statements for rationalizing AST use.
- To address concerns of PPI overuse and associated adverse effects.
- To develop a PPI deprescribing algorithm.
Main Methods:
- A three-step modified Delphi polling process.
- A multidisciplinary expert panel of 13 health professionals.
- Comprehensive review of scientific literature and clinical expertise.
Main Results:
- 21 consensus statements on the general use and safety of acid suppressants.
- A PPI deprescribing algorithm was collaboratively developed.
- Evidence-based recommendations for rational AST use.
Conclusions:
- The consensus provides guidance for primary care practitioners.
- Aims to improve patient outcomes and minimize healthcare costs.
- Enhances patient safety by curtailing inappropriate usage.
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