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Cognitive complaint inversely associated to UHR transition
Mirvat Hamdan-Dumont1,2,3, Laurent Lecardeur4, Marine Habert1
1Centre Hospitalier Esquirol, Early Intervention Unit, Limoges 87000, France.
Schizophrenia Research. Cognition
|July 18, 2024
Summary
Ultra-High Risk (UHR) youth experiencing psychotic transition were identified. Self-reported cognitive complaints may indicate a protective factor against psychotic transition in these at-risk youth.
Area of Science:
- Psychiatry
- Developmental Psychology
- Neuroscience
Background:
- Ultra-High Risk (UHR) for psychosis is a critical period for early intervention.
- Identifying predictors of transition to psychosis is crucial for timely clinical management.
Purpose of the Study:
- To investigate the impact of clinical determinants on the six-month transition to psychosis in UHR youth.
- To identify potential protective factors against psychotic transition.
Main Methods:
- Longitudinal study monitoring UHR youth over six months.
- Clinical assessments included unusual thought content and cognitive complaints.
- Statistical analysis using log-rank and odds ratios (OR) to determine transition predictors.
Main Results:
- 13 out of 39 UHR subjects (35.2%) transitioned to psychosis; none of the non-psychotic controls did (p < 0.001).
- Unusual Thought Content was significantly associated with psychotic transition (OR 8.57).
- Self-reported cognitive complaint showed an inverse association with transition (OR 0.13), suggesting a protective effect.
Conclusions:
- Clinical staging and specific symptoms impact psychotic transition in UHR youth.
- Self-reported cognitive complaint may serve as a protective marker, warranting further investigation.
- Early identification of protective factors is vital for UHR youth at risk for psychosis.
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