Related Experiment Video

Updated: Jun 20, 2025

Expression and Purification of the Human Lipid-sensitive Cation Channel TRPC3 for Structural Determination by Single-particle Cryo-electron Microscopy
08:27

Expression and Purification of the Human Lipid-sensitive Cation Channel TRPC3 for Structural Determination by Single-particle Cryo-electron Microscopy

Published on: January 7, 2019

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The roles of TRPC6 in renal tubular disorders: a narrative review

Aiqin Sheng1, Fei Liu1, Qianhui Wang1

  • 1Department of Nephrology, Children's Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Renal Failure
|July 18, 2024
PubMed

Insights

The transient receptor potential canonical 6 (TRPC6) channel is crucial in kidney diseases, impacting renal tubules. Further research into TRPC6 pathophysiology is vital for developing new therapeutic targets for kidney disorders.

Area of Science:

  • Nephrology
  • Molecular Biology
  • Physiology

Background:

  • Transient receptor potential canonical 6 (TRPC6) is a nonselective cation channel involved in Ca2+ influx.
  • TRPC6 activation is triggered by Ca2+ influx, oxidative stress, and mechanical stress.
  • TRPC6 is implicated in glomerular diseases and renal tubular disorders like acute kidney injury, fibrosis, and renal cell carcinoma (RCC).

Purpose of the Study:

  • To review the importance of TRPC6 in the renal tubular system.
  • To elucidate the tubule-specific physiological functions of TRPC6.
  • To clarify the pathophysiological role of TRPC6 in renal disorders, including ischemia/reperfusion (I/R) injury and RCC.

Main Methods:

  • Literature review of studies on TRPC6 in renal diseases.
  • Analysis of TRPC6's role in various renal injury models, including unilateral ureteral obstruction (UUO).
  • Examination of TRPC6's impact on cell cycle regulation and genomic instability in RCC.

Main Results:

  • TRPC6 contributes to renal fibrosis and immune cell infiltration in a UUO mouse model.
  • TRPC6 overexpression may affect G2 phase transition, leading to genomic instability and RCC tumorigenesis.
  • TRPC6 plays a role in the proliferation of RCC cells.

Conclusions:

  • TRPC6 is important in various renal tubular conditions.
  • TRPC6 may have dual roles in I/R injury.
  • Clarifying TRPC6 pathophysiology is essential for identifying new therapeutic targets for renal diseases.
Keywords:
Renal tubular systemrenal cell carcinomarenal interstitial fibrosisrenal ischemia/reperfusion injurytransient receptor potential 6

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