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Inactivated cGAS-STING Signaling Facilitates Endocrine Resistance by Forming a Positive Feedback Loop with AKT Kinase

Kai-Ming Zhang1,2, De-Chang Zhao1,2, Ze-Yu Li3,4

  • 1State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou, 510060, China.

Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
|July 18, 2024
PubMed
Summary

Endocrine-resistant breast cancer shows reduced innate immune signaling due to AKT1-mediated cGAS-STING pathway inhibition. Combining AKT1 inhibitors with STING agonists may offer a novel therapeutic strategy for this aggressive cancer.

Keywords:
AKT kinasecGAS‐STING pathwayendocrine‐resistant breast cancerpositive feedback loop

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