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Updated: Jun 20, 2025

Versatile CO2 Transformations into Complex Products: A One-pot Two-step Strategy
Published on: November 9, 2019
Photocatalytic Three-Component Acylcarboxylation of Alkenes with CO2
Taito Watanabe1, Phurinat Lorwongkamol1, Yutaka Saga1,2
1Division of Applied Chemistry, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka 565-0871, Japan.
Abstract:
γ-Keto acid is a valuable chemical motif in a wide range of fields including organic, biological, and medicinal chemistry. However, its single-step synthesis is challenging because of the mismatch of the carbonyl polarity and low tolerance of carboxylic acids. Herein, we report the single-step syntheses of γ-keto acids using alkenes and CO2. Our photocatalytic system enabled the transformation of alkenes under mild conditions in high yields (up to 95%) with broad substrate generality (35 examples).
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