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Published on: April 19, 2019
Fluorohalomethylsulfonium Salts as a Fluorohalocarbene Source
Arturs Sperga1, Toms Pfeifers1, Dzintars Zacs2
1Latvian Institute of Organic Synthesis, Aizkraukles 21, LV-1006 Riga, Latvia.
Abstract:
Synthesis of fluoroorganic compounds is of great importance due to their extensive application in medicinal chemistry, agrochemicals, and materials. Herein, we report efficient synthesis of novel diaryl fluorohalomethyl sulfonium salts. The application showcased proficient reagents for Freon-free fluorochloro-, fluorobromo-, and fluoroiodocarbene transfer to alkenes. The developed mild, room temperature conditions for the cyclopropanation do not require any metal catalysts and allow synthetic access to diverse cyclopropanes.
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