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Updated: Apr 6, 2026
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Generic Protocol for Optimization of Heterologous Protein Production Using Automated Microbioreactor Technology
Published on: December 15, 2017
10.0K
Single-cell protein: overcoming technological and biological challenges towards improved industrialization
Lijuan Ye1, Biljana Bogicevic1, Christoph J Bolten1
1Nestlé Research, Lausanne, Switzerland.
Current Opinion in Biotechnology
|July 18, 2024
Summary
Single-cell protein (SCP) offers sustainable food solutions but faces cost and scale challenges. This study analyzes manufacturing processes to identify key innovations for cost-efficient, large-scale SCP production.
Area of Science:
- Biotechnology
- Sustainable Food Production
- Industrial Microbiology
Background:
- Single-cell protein (SCP) production from microbial fermentation has existed for decades, with early commercial examples like Pruteen (animal feed) and Quorn® (human nutrition).
- SCP is recognized for its potential to contribute to sustainable food security for a growing global population.
- Current limitations in SCP application stem from high production costs and challenges in achieving large-scale availability.
Purpose of the Study:
- To review the current state-of-the-art in single-cell protein manufacturing.
- To provide comprehensive techno-economic and life-cycle assessment insights into various SCP production scenarios.
- To identify critical technical challenges and opportunities for optimizing SCP production efficiency and cost-effectiveness.
Main Methods:
- Review of existing literature on single-cell protein (SCP) manufacturing processes.
- Analysis of techno-economic assessments (TEAs) for different SCP production routes.
- Evaluation of life-cycle assessments (LCAs) to understand environmental impacts.
- Identification of key process components and innovation priorities.
Main Results:
- The study identifies critical technical 'hotspots' and challenges within major SCP production scenarios.
- Techno-economic and life-cycle assessments highlight areas for process optimization.
- Key factors influencing cost efficiency and large-scale production viability are pinpointed.
Conclusions:
- Optimizing manufacturing processes is essential to overcome cost and scale limitations in single-cell protein (SCP) production.
- Targeted innovations in key process components can enhance affordability and productivity.
- Further research and development are needed to fully realize the potential of SCP as a sustainable food source.
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