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Functional and structural insights into RAS effector proteins
Alessandro M Mozzarelli1, Dhirendra K Simanshu2, Pau Castel1
1Department of Biochemistry and Molecular Pharmacology, NYU Grossman School of Medicine, New York, NY, USA; Laura and Isaac Perlmutter NYU Cancer Center, NYU Langone Health, New York, NY, USA.
Molecular Cell
|July 18, 2024
Summary
RAS proteins are molecular switches crucial for cell processes. This review details RAS effector proteins, their interactions, and therapeutic potential in RAS-mediated signaling.
Area of Science:
- Molecular biology
- Cellular signaling
- Biochemistry
Background:
- RAS proteins function as guanosine triphosphate (GTP) hydrolases, acting as molecular switches in cellular processes.
- Activated RAS GTPases interact with specific RAS effector proteins, initiating downstream signaling pathways.
- Over 50 human RAS effector proteins are known, with many implicated in RAS-dependent signaling.
Purpose of the Study:
- To review the mechanisms and functions of known RAS effector proteins.
- To provide structural insights into RAS-effector interactions.
- To explore the significance of RAS-effector complexes in signaling and their therapeutic potential.
Main Methods:
- Literature review of biochemical and structural analyses of RAS effectors.
- Examination of studies using model organisms to understand RAS-effector roles.
- Analysis of existing data on RAS-mediated signaling pathways.
Main Results:
- Detailed discussion of identified RAS effector proteins and their functions.
- Structural perspectives on the dynamics of RAS-effector complex formation.
- Evaluation of the significance of these interactions in cellular signaling and disease.
Conclusions:
- While much is known, critical aspects of RAS-effector complex dynamics and biological functions require further elucidation.
- Understanding RAS-effector interactions is vital for deciphering RAS-mediated signaling.
- RAS effector proteins represent promising therapeutic targets for diseases involving RAS signaling.
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