Related Experiment Video

Updated: Jun 20, 2025

Exploring m6A and m5C Epitranscriptomes upon Viral Infection: an Example with HIV
14:40

Exploring m6A and m5C Epitranscriptomes upon Viral Infection: an Example with HIV

Published on: March 5, 2022

3.2K

m6A epitranscriptomic and epigenetic crosstalk in liver fibrosis: Special emphasis on DNA methylation and non-coding

Qi-Qi Dong1, Yang Yang2, Hui Tao3

  • 1Department of Clinical Pharmacology, The Second Affiliated Hospital of Anhui Medical University, Hefei 230601, China; School of Pharmacy, Anhui Medical University, Hefei 230032, China.

Cellular Signalling
|July 18, 2024
PubMed

Insights

Liver fibrosis treatments are limited. This review explores how N6-methyladenosine (m6A) modification, non-coding RNA, and DNA methylation influence liver fibrosis, offering new therapeutic insights.

Area of Science:

  • Molecular biology
  • Hepatology
  • Epigenetics

Background:

  • Liver fibrosis is a significant pathological process in chronic liver diseases with limited therapeutic options.
  • Epigenetic and epitranscriptomic modifications are increasingly recognized as key players in liver fibrosis development.
  • Understanding these reversible regulatory mechanisms is crucial for developing novel treatments.

Purpose of the Study:

  • To review the regulatory mechanisms of N6-methyladenosine (m6A) modification, non-coding RNA, and DNA methylation in organ fibrosis.
  • To explore the interplay between epitranscriptomics and epigenetics in the context of liver fibrosis.
  • To provide a reference for understanding the pathogenesis and potential therapeutic targets in chronic liver diseases.

Main Methods:

  • Literature review focusing on epigenetic and epitranscriptomic modifications in liver fibrosis.
  • Analysis of regulatory mechanisms involving N6-methyladenosine (m6A) modification, non-coding RNA, and DNA methylation.
  • Discussion of the interactions between m6A modification and DNA methylation, and between m6A modification and non-coding RNA.

Main Results:

  • N6-methyladenosine (m6A) modification, non-coding RNA, and DNA methylation are integral to the development of liver fibrosis.
  • Complex interactions exist between m6A modification, DNA methylation, and non-coding RNA in fibrogenesis.
  • These epigenetic and epitranscriptomic mechanisms offer potential avenues for therapeutic intervention.

Conclusions:

  • Epigenetic and epitranscriptomic modifications, particularly m6A, non-coding RNA, and DNA methylation, are critical in liver fibrosis.
  • Understanding the intricate interplay between these mechanisms provides valuable insights into chronic liver disease pathogenesis.
  • Targeting these epigenetic regulators may lead to the development of innovative therapies for liver fibrosis.
Keywords:
DNA MethylationEpigeneticEpitranscriptomicLiver Fibrosism6A modificaion

More Related Videos

Methyl-binding DNA capture Sequencing for Patient Tissues08:40

Methyl-binding DNA capture Sequencing for Patient Tissues

Published on: October 31, 2016

8.6K
Methylated DNA Immunoprecipitation21:24

Methylated DNA Immunoprecipitation

Published on: January 2, 2009

23.3K

Related Concept Videos

Epigenetic Regulation01:37

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
3.0K
Cell Specific Gene Expression01:58

Cell Specific Gene Expression

Multicellular organisms contain a variety of structurally and functionally distinct cell types, but the DNA in all the cells originated from the same parent cells. The differences in the cells can be attributed to the differential gene expression. Liver cells, whose functions include detoxification of blood, production of bile to metabolize fats, and synthesis of proteins essential for metabolism, must express a specific set of genes to perform their functions. Gene expression also varies with...
13.6K
Histone Modification02:32

Histone Modification

The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
Acetylation
The enzyme histone acetyltransferase adds acetyl group to the histones. Another enzyme, histone...
13.2K
Spreading of Chromatin Modifications02:25

Spreading of Chromatin Modifications

The histone proteins in the nucleosomes are post-translationally modified (PTM) to increase or decrease access to DNA. The commonly observed PTMs are methylation, acetylation, phosphorylation, and ubiquitination of lysine amino acids in the histone H3 tail region. These histone modifications have specific meaning for the cell. Hence, they are called "histone code". The protein complex involved in histone modification is termed as "reader-writer" complex.
Writers
The writer...
8.2K
Inheritance of Chromatin Structures03:17

Inheritance of Chromatin Structures

Epigenetics is the study of inherited changes in a cell's phenotype without changing the DNA sequences. It provides a form of memory for the differential gene expression pattern to maintain cell lineage, position-effect variegation, dosage compensation, and maintenance of chromatin structures such as telomeres and centromeres. For example, the structure and location of the centromere on chromosomes are epigenetically inherited. Its functionality is not dictated or ensured by the underlying...
6.2K
Master Transcription Regulators02:23

Master Transcription Regulators

Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a  complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...
6.9K