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Topical prebiotic nitrate: optimizing the 'hang-time', source and dose for specific oral or systemic effects
1Department of Genomics and Health, FISABIO Foundation, Valencia, Spain. bob.rosier@fisabio.es.
NPJ Biofilms and Microbiomes
|July 18, 2024
Summary
Nitrate product
Area of Science:
- Nutritional Science
- Oral Biology
Background:
- Dietary nitrate intake is explored for therapeutic applications.
- The 'hang-time' of nitrate delivery is a novel consideration for product design.
Discussion:
- Longer nitrate 'hang-time' may not always be superior due to salivary recycling.
- Extending 'hang-time' is beneficial for targeting oral tissues and individuals with reduced salivary flow.
- Nitrate dose, source, and desired effect (oral vs. systemic) are critical variables.
Key Insights:
- Nitrate 'hang-time' influences therapeutic strategies.
- Oral tissue exposure and salivary flow impairment are key applications for extended 'hang-time'.
- Salivary microbiota changes require placebo-controlled validation.
Outlook:
- Further research is needed to optimize nitrate delivery systems.
- Placebo-controlled studies are essential to confirm the effects of nitrate products on oral microbiota.
- Understanding nitrate metabolism and oral microbiome interactions is crucial for future applications.
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