Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pulmonary Cycle: Exhalation01:17

Pulmonary Cycle: Exhalation

1.5K
In terms of human respiration, the act of expelling air, known as exhalation (or expiration), operates on the principle of pressure gradients. During expiration, the pressure within the lungs exceeds that of the surrounding atmosphere. Under normal conditions, quiet breathing involves passive exhalation and is free of muscular contractions. This is because the exhalation process is driven by the natural elastic recoil of the lungs and chest wall, both of which have an inherent tendency to...
1.5K
Chronic Obstructive Pulmonary Disease-II: Pathophysiology01:20

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

2.8K
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
2.8K
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

438
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
438
The Bronchial Tree01:23

The Bronchial Tree

2.3K
The human bronchi and bronchial tree play a crucial role in the respiratory system, facilitating the exchange of oxygen and carbon dioxide. Let's delve into the intricate structure and functions of these respiratory components.
The trachea, commonly known as the windpipe, is a tube that connects the larynx (voice box) to the bronchi. At a point called the carina, it bifurcates into two primary bronchi. The right primary bronchus is wider, shorter, and more vertical than the left primary...
2.3K
Cystic Fibrosis: Pathogenesis01:23

Cystic Fibrosis: Pathogenesis

202
Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
202
Pulmonary Tuberculosis II01:28

Pulmonary Tuberculosis II

215
Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
215

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Real-world Outcomes of Nebulized Levofloxacin in Chronic Bronchial Infection Not Associated with Cystic Fibrosis: A Comparative Analysis From the INBREATHING Registry.

Archivos de bronconeumologia·2026
Same author

Frequent exacerbators and neutrophil elastase activity in bronchiectasis: a network analysis approach.

ERJ open research·2026
Same author

From Lungs to Vascular Health: Airflow Obstruction, Not Lung Function Decline, Predicts Atherosclerosis Progression Independent of Smoking Status.

Archivos de bronconeumologia·2026
Same author

Dual-range colorimetric protein quantification in whey and WPC using a smart polymeric film and RGB imaging.

Food chemistry·2026
Same author

Dupilumab-induced eosinophilia in severe asthma: 2-year follow-up real-life evidence from biologic-naïve and previously treated patients.

Respiratory medicine·2026
Same author

Diagnostic challenges and management of primary accessory axillary breast cancer.

BMJ case reports·2026
Same journal

When Pneumonia is not Pneumonia: Pulmonary Venous Thrombosis After Scimitar Syndrome Repair.

Open respiratory archives·2026
Same journal

Building the Future of Interventional Pulmonology: Reflections from the Forum of La Gomera.

Open respiratory archives·2026
Same journal

[Sepsis in the Intermediate Respiratory Care Unit: Restrospective Study].

Open respiratory archives·2026
Same journal

Pulmonary Mass as a Rare Pulmonary Manifestation of Inflammatory Bowel Disease.

Open respiratory archives·2026
Same journal

[BioSAT: Development and conceptual validation of a satisfaction questionnaire regarding biologic therapies for severe asthma through a structured patient-professional co-creation process].

Open respiratory archives·2026
Same journal

Nintedanib in a Dialysis Patient with Idiopathic Pulmonary Fibrosis: A One-Year Follow-Up Without Major Adverse Events.

Open respiratory archives·2026
See all related articles

Related Experiment Video

Updated: Jun 20, 2025

Long Term Chronic Pseudomonas aeruginosa Airway Infection in Mice
15:43

Long Term Chronic Pseudomonas aeruginosa Airway Infection in Mice

Published on: March 17, 2014

22.7K

Bronchiectasis.

Beatriz Raboso1, Cristina Pou2, Rosa Abril3

  • 1Getafe University Hospital, Madrid, Spain.

Open Respiratory Archives
|July 19, 2024
PubMed
Summary
This summary is machine-generated.

Precision medicine advances non-cystic fibrosis bronchiectasis diagnosis and treatment. Novel imaging and molecular profiling identify patient endotypes for tailored therapies, improving clinical outcomes.

Keywords:
BronchiectasisBronchiectasis endotypesLung microbiome

More Related Videos

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma
14:39

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

Published on: November 4, 2010

31.9K
Author Spotlight: Evaluating the Therapeutic Efficacy of Moving Cupping Along Meridians for Acute Exacerbation of COPD
04:03

Author Spotlight: Evaluating the Therapeutic Efficacy of Moving Cupping Along Meridians for Acute Exacerbation of COPD

Published on: September 27, 2024

647

Related Experiment Videos

Last Updated: Jun 20, 2025

Long Term Chronic Pseudomonas aeruginosa Airway Infection in Mice
15:43

Long Term Chronic Pseudomonas aeruginosa Airway Infection in Mice

Published on: March 17, 2014

22.7K
Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma
14:39

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

Published on: November 4, 2010

31.9K
Author Spotlight: Evaluating the Therapeutic Efficacy of Moving Cupping Along Meridians for Acute Exacerbation of COPD
04:03

Author Spotlight: Evaluating the Therapeutic Efficacy of Moving Cupping Along Meridians for Acute Exacerbation of COPD

Published on: September 27, 2024

647

Area of Science:

  • Pulmonology
  • Precision Medicine
  • Medical Diagnostics

Background:

  • Non-cystic fibrosis bronchiectasis is underrecognized, posing diagnostic challenges.
  • Recent research advances diagnostic methods and molecular profiling for personalized treatment.

Purpose of the Study:

  • To review advancements in diagnosing and treating non-cystic fibrosis bronchiectasis.
  • To highlight the role of precision medicine in tailoring therapies based on patient endotypes.

Main Methods:

  • Computed tomography (CT) remains standard, with emerging AI algorithms, ultra-low dose CT, and MRI.
  • Analysis of inflammatory profiles and biomarkers (neutrophil elastase, mucins, antimicrobial peptides) to define patient endotypes.
  • Investigating the microbiome's role using interactome analysis.

Main Results:

  • Novel diagnostic tools are becoming feasible.
  • Distinct patient endotypes with variable outcomes have been identified.
  • Personalized treatments, including inhaled mannitol, brensocatib, and inhaled corticosteroids for eosinophilic bronchiectasis, are being developed.

Conclusions:

  • Precision medicine is revolutionizing bronchiectasis care through advanced diagnostics and tailored therapies.
  • Understanding patient endotypes and the multibiome is crucial for effective treatment strategies.