Related Experiment Video

Updated: Jun 20, 2025

Genome-wide Screen for miRNA Targets Using the MISSION Target ID Library
08:40

Genome-wide Screen for miRNA Targets Using the MISSION Target ID Library

Published on: April 6, 2012

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Role of miRNA‑122 in cancer (Review)

Jing Zhang1, Linghua Wu2, Rong Ding1

  • 1Department of Respiratory Medicine, Taizhou Fourth People's Hospital, Taizhou, Jiangsu 225300, P.R. China.

International Journal of Oncology
|July 19, 2024
PubMed

Insights

MicroRNA-122 (miRNA-122) plays a complex role in cancer, acting as both a tumor suppressor and oncogene. This review explores its functions, diagnostic potential, and therapeutic implications in cancer treatment.

Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • MicroRNAs (miRNAs) are small non-coding RNAs regulating gene expression.
  • miRNA-122's role in cancer is dual, acting as a tumor suppressor or oncogene.
  • Its precise function in tumor progression requires further elucidation.

Purpose of the Study:

  • To review the multifaceted roles of miRNA-122 in various cancers.
  • To assess miRNA-122 as a potential biomarker for cancer diagnosis and prognosis.
  • To explore miRNA-122's implications in radiotherapy and chemotherapy.

Main Methods:

  • Literature review of studies on miRNA-122 in cancer.
  • Analysis of miRNA-122's gene-targeting mechanisms.
  • Evaluation of its potential as a therapeutic agent and biomarker.

Main Results:

  • miRNA-122 influences cell proliferation, migration, invasion, and apoptosis.
  • It shows potential as a biomarker for early cancer detection and predicting patient outcomes.
  • miRNA-122 can modulate responses to radiotherapy and chemotherapy.

Conclusions:

  • miRNA-122 is a significant factor in cancer development and progression.
  • It holds promise as a diagnostic and prognostic biomarker.
  • Targeting miRNA-122 or utilizing it as a therapeutic agent warrants further investigation for cancer treatment strategies.
Keywords:
apoptosisbiomarkerchemotherapymalignancymicroRNA‑122oncogenetumor suppressor

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