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Refractory migraine headache controlled with alprazolam: case report.
The Journal of Clinical Psychiatry
|November 1, 1985
Summary
Alprazolam effectively controlled severe migraine headaches in a patient with major depressive disorder. Migraine symptoms returned after stopping the medication, indicating its potential for managing refractory migraine.
Area of Science:
- Neurology
- Psychiatry
Background:
- Major depressive disorder (MDD) and refractory migraine headaches often co-occur.
- Treatment-resistant migraine poses a significant challenge in clinical practice.
Observation:
- A single patient diagnosed with MDD and incapacitating, refractory migraines was studied.
- The patient received alprazolam in a double-blind, placebo-controlled trial.
Findings:
- Alprazolam demonstrated efficacy in managing the patient's refractory migraine headaches.
- Upon drug tapering, migraine recurrence was observed, while depressive symptoms did not reappear.
Implications:
- These findings suggest alprazolam may be a viable therapeutic option for refractory migraine.
- Further research is warranted to confirm alprazolam's efficacy and safety in larger patient cohorts for migraine management.