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Related Experiment Videos

Refractory migraine headache controlled with alprazolam: case report.

S C Othmer, E Othmer, T M Varanka

    The Journal of Clinical Psychiatry
    |November 1, 1985
    PubMed
    Summary

    Alprazolam effectively controlled severe migraine headaches in a patient with major depressive disorder. Migraine symptoms returned after stopping the medication, indicating its potential for managing refractory migraine.

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    Area of Science:

    • Neurology
    • Psychiatry

    Background:

    • Major depressive disorder (MDD) and refractory migraine headaches often co-occur.
    • Treatment-resistant migraine poses a significant challenge in clinical practice.

    Observation:

    • A single patient diagnosed with MDD and incapacitating, refractory migraines was studied.
    • The patient received alprazolam in a double-blind, placebo-controlled trial.

    Findings:

    • Alprazolam demonstrated efficacy in managing the patient's refractory migraine headaches.
    • Upon drug tapering, migraine recurrence was observed, while depressive symptoms did not reappear.

    Implications:

    • These findings suggest alprazolam may be a viable therapeutic option for refractory migraine.

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  • Further research is warranted to confirm alprazolam's efficacy and safety in larger patient cohorts for migraine management.