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Updated: Jun 20, 2025

Facile Preparation of 4-Substituted Quinazoline Derivatives
Published on: February 15, 2016
Electrorearranged Difunctionalization of 4-Hydroxy-α-benzopyrones
Indrajit Karmakar1, Goutam Brahmachari1
1Laboratory of Natural Products & Organic Synthesis, Department of Chemistry, Visva-Bharati (a Central University), Santiniketan-731 235, West Bengal, India.
Abstract:
We herein report the exploration of an electrosynthetic strategy as a highly efficient and straightforward alternative protocol for accessing diversely substituted and biologically promising alkyl 2-hydroxy-3-oxo-2,3-dihydrobenzofuran-2-carboxylates through an electrorearranged difunctionalization of 4-hydroxycoumarins, involving the singlet oxygen insertion from molecular oxygen, at ambient temperature. The present method is notably more advantageous than the previously reported photochemical conversion regarding yields and reaction times, substrate scope and functional group tolerability, operational simplicity, and scalability.
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