Changes in plasma fibronectin during allogeneic bone marrow transplantation

Plasma fibronectin concentrations were measured serially in nine patients undergoing allogeneic bone marrow transplantation. Concentrations were reduced by conditioning treatment and episodes of bacterial infection. Acute graft versus host disease may exacerbate or prolong this process. Reduced plasma fibronectin concentrations impair the function of the mononuclear phagocyte system and the maintenance of capillary endothelial integrity and may thus contribute to the morbidity and mortality in patients undergoing bone marrow transplantation.