Related Experiment Video For Analysis of lesion changes
Updated: Jun 20, 2025
Brain Infarct Segmentation and Registration on MRI or CT for Lesion-symptom Mapping
Published on: September 25, 2019
A graph-theoretic approach for the analysis of lesion changes and lesions detection review in longitudinal
Beniamin Di Veroli1, Richard Lederman2, Yigal Shoshan3
1School of Computer Science and Engineering, The Hebrew University of Jerusalem, Israel.
Abstract:
Radiological follow-up of oncology patients requires the detection of lesions and the quantitative analysis of lesion changes in longitudinal imaging studies of patients, which is time-consuming and requires expertise. We present here a new method and workflow for the analysis and review of lesions and volumetric lesion changes in longitudinal scans of a patient. The generic graph-based method consists of lesion matching, classification of changes in individual lesions, and detection of patterns of lesion changes computed from the properties of the graph and its connected components. The workflow guides clinicians in the detection of missed lesions and wrongly identified lesions in manual and computed lesion annotations using the analysis of lesion changes. It serves as a heuristic method for the automatic revision of ground truth lesion annotations in longitudinal scans. The methods were evaluated on longitudinal studies of patients with three or more examinations of metastatic lesions in the lung (19 patients, 83 CT scans, 1178 lesions), the liver (18 patients, 77 CECT scans, 800 lesions) and the brain (30 patients, 102 T1W-Gad MRI scans, 317 lesions) with ground-truth lesion annotations. Lesion matching yielded a precision of 0.92-1.0 and recall of 0.91-0.99. The classification of changes in individual lesions yielded an accuracy of 0.87-0.97. The classification of patterns of lesion changes yielded an accuracy of 0.80-0.94. The lesion detection review workflow applied to manual and computed lesion annotations yielded 120 and 55 missed lesions and 20 and 164 wrongly identified lesions for all longitudinal studies of patients, respectively. The automatic analysis of lesion changes and review of lesion detection in longitudinal studies of oncological patients helps detect missed lesions and wrongly identified lesions. This method may help improve the accuracy of radiological interpretation and the disease status evaluation.
