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Updated: Jun 20, 2025
Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging
Published on: November 8, 2012
Comparison of apparent diffusion coefficient (ADC) values obtained by echo planar imaging diffusion-weighted imaging
1Department of Radiological Technology, Kagoshima Medical Technology College, Japan.
Introduction:
Diffusion-weighted imaging (DWI) with radial acquisition regime (RADAR; RADAR-DWI) is a fast spin echo (FSE)-based DWI imaging technique that is known to be robust to magnetic susceptibility artifacts and distortions as compared with echo planar imaging DWI (EPI-DWI). Several reports have suggested that the apparent diffusion coefficient (ADC) values obtained with FSE-based DWI are different from those obtained with EPI-DWI. The purpose of this study was to create phantoms that mimic the T2 and ADC values of various tissues and to demonstrate the ADC values obtained with RADAR-DWI and EPI-DWI in low-field magnetic resonance imaging (MRI) systems.
Methods:
Several phantoms were created using sucrose and manganese (II) chloride tetrahydrate mimicking various tissues. RADAR-DWI and EPI-DWI were used to scan the phantoms, and the obtained ADC values were compared.
Results:
The ADC values obtained with RADAR-DWI were significantly higher than those obtained with EPI-DWI for all phantoms (P < 0.05). The ADC values obtained by RADAR-DWI ranged from 0.70 ± 0.01 to 1.21 ± 0.02 ( × 10-3mm2s-1). Meanwhile, the ADC values obtained with EPI-DWI ranged from 0.59 ± 0.01 to 1.08 ± 0.05 ( × 10-3mm2s-1).
Conclusions:
We created phantoms mimicking T2 and ADC values of various tissues and demonstrated the differences in ADC values obtained with RADAR-DWI and EPI-DWI using low-field MRI systems.
Implications For Practice:
ADC values obtained by RADAR-DWI are significantly higher than those obtained by EPI-DWI, with different cutoff values for various tumor malignancies between them.
