Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Antibody Structure

Antibody Structure

Overview
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
Antibodies consist of four polypeptide chains: two identical heavy...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

[Teaching head and neck ultrasound : Current educational formats and assessment structures and their potential influence on future curriculum development].

HNO·2025

Same author

Risk profile for recurrence after interdisciplinary treatment of odontogenic maxillary sinusitis: experience of a single centre.

Oral surgery, oral medicine, oral pathology and oral radiology·2025

Same author

[Temporary postoperative care with the bone conduction hearing system ADHEAR© : A prospective study on 76 patients].

HNO·2025

Same author

Tinnitus as an Indication of Head Injury.

Deutsches Arzteblatt international·2024

Same author

[Allergen immunotherapy for rare allergens].

HNO·2024

Same author

Long-term benefits of EPs<sup>®</sup> 7630 in patients with acute sinusitis: a real-world cohort study.

Frontiers in pharmacology·2024

Search research articles

Related Experiment Video

Updated: Jun 20, 2025

Absorption of Nasal and Bronchial Fluids: Precision Sampling of the Human Respiratory Mucosa and Laboratory Processing of Samples

Absorption of Nasal and Bronchial Fluids: Precision Sampling of the Human Respiratory Mucosa and Laboratory Processing of Samples

Published on: January 21, 2018

[Immunoglobulin E in nasal secretions].

Guido Mühlmeier¹, Matthias Tisch²

¹Klinik für Hals-Nasen-Ohren-Heilkunde, Kopf- und Halschirurgie, Bundeswehrkrankenhaus Ulm, Oberer Eselsberg 40, 89081, Ulm, Deutschland. gmhno@t-online.de.

|July 20, 2024

Summary

Diagnosing allergic disease often involves immunoglobulin E (IgE) blood tests. Analyzing IgE in nasal secretions, though challenging, can help differentiate local allergic rhinitis from nonallergic rhinitis when other tests are negative.

Keywords:

Hypersensitivity Immune system Perennial allergic rhinitis Seasonal allergic rhinitis Staphylococcal enterotoxins

More Related Videos

Author Spotlight: Advancing Allergic Rhinitis Research with Multicolor Immunofluorescence

Author Spotlight: Advancing Allergic Rhinitis Research with Multicolor Immunofluorescence

Published on: September 22, 2023

Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber

Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber

Published on: March 3, 2023

Related Experiment Videos

Last Updated: Jun 20, 2025

Absorption of Nasal and Bronchial Fluids: Precision Sampling of the Human Respiratory Mucosa and Laboratory Processing of Samples

Absorption of Nasal and Bronchial Fluids: Precision Sampling of the Human Respiratory Mucosa and Laboratory Processing of Samples

Published on: January 21, 2018

Author Spotlight: Advancing Allergic Rhinitis Research with Multicolor Immunofluorescence

Author Spotlight: Advancing Allergic Rhinitis Research with Multicolor Immunofluorescence

Published on: September 22, 2023

Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber

Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber

Published on: March 3, 2023

Area of Science:

Allergy and Immunology
Diagnostic Medicine

Background:

Allergic disease diagnosis commonly relies on serum immunoglobulin E (IgE) analysis.
Analyzing IgE in nasal secretions presents technical challenges due to low sample volume and collection methods.

Purpose of the Study:

To explore the utility of IgE detection in nasal secretions for diagnosing allergic conditions.
To differentiate between local allergic rhinitis and nonallergic rhinitis, especially when skin and serum tests are inconclusive.

Main Methods:

Qualitative diagnostics via nasal lavage.
Quantitative analyses using swabs for defined mucus amounts.
Detection of IgE in nasal mucus combined with nasal provocation testing.

Main Results:

Nasal secretion IgE analysis is technically demanding but feasible.
Quantitative analysis is possible with swab-based mucus collection.
Combined nasal IgE detection and provocation testing aid in differentiating rhinitis types.

Conclusions:

IgE determination in nasal secretions offers a complementary diagnostic approach.
This method is particularly valuable for diagnosing local allergic rhinitis when systemic tests are negative.
Improved methods for nasal secretion collection and analysis are crucial for clinical application.