Related Experiment Video
Updated: Jun 20, 2025

Improving IV Insulin Administration in a Community Hospital
Published on: June 11, 2012
Insulin Icodec: First Approval
1Springer Nature, Private Bag 65901, Mairangi Bay, Auckland, 0754, New Zealand. bdr@adis.com.
Insulin icodec, a new ultra-long-acting basal insulin, offers a once-weekly injection for improved diabetes management. Recent approvals in Switzerland, Canada, and the EU mark significant milestones for this novel treatment.
Area of Science:
- Endocrinology
- Pharmacology
- Diabetes Mellitus Treatment
Background:
- Insulin icodec (AWIQLI®) is an investigational ultra-long-acting basal insulin analogue.
- It is developed for subcutaneous injection once weekly for diabetes mellitus management.
- Current basal insulin therapies are typically administered once daily.
Purpose of the Study:
- To summarize the development milestones of insulin icodec.
- To highlight the recent regulatory approvals for insulin icodec.
- To provide an overview of insulin icodec's potential in diabetes treatment.
Main Methods:
- Review of preclinical and clinical development data.
- Analysis of regulatory submission and approval timelines.
- Summary of key characteristics of insulin icodec.
Main Results:
- Insulin icodec is an ultra-long-acting basal insulin analogue.
- It is administered once weekly via subcutaneous injection.
- Received regulatory approval in Switzerland (March 2024), Canada (March 2024), and the EU (May 2024) for treating diabetes mellitus in adults.
Conclusions:
- Insulin icodec represents a significant advancement in basal insulin therapy.
- The once-weekly dosing aims to enhance treatment adherence and glycemic control.
- Recent approvals pave the way for wider clinical adoption in diabetes management.
Related Concept Videos
Oral Hypoglycemic Agents: Glinides
Insulin Formulations: Types and Delivery
Short-acting insulins are divided into...
Insulin: Biosynthesis, Chemistry, and Preparation
Damage or functional impairment of β-cells inhibits insulin production, leading to diabetes. Diabetes treatment...
Insulin: Dosing Regimen and Adverse Effects
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...
Dipeptidyl Peptidase 4 Inhibitors
Insulin: The Receptor and Signaling Pathways

