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Natural Affinity Driven Modification by Silicene to Construct a "Thermal Switch" for Tumorous Bone Loss.
Yi-Xing Chen1, Yi-Ping Luo1, Xiao-Dong Hou1
1Department of Orthopedics, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, 200072, China.
Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
|July 21, 2024
Summary
This study introduces a smart bone scaffold (SNS@DBM) that uses a "thermal switch" to treat bone defects after tumor removal. It helps prevent recurrence and regenerate bone by controlling heat stimulation.
Area of Science:
- Biomaterials Science
- Regenerative Medicine
- Oncology
Background:
- Tumorous bone defects pose reconstruction challenges due to residual tumors and bone loss.
- Current treatments lack integrated solutions for simultaneous tumor ablation and bone regeneration.
Purpose of the Study:
- To develop a smart bone scaffold (SNS@DBM) for sequential thermotherapy in tumorous bone defects.
- To investigate the scaffold's ability to ablate residual tumors, prevent recurrence, and promote bone regeneration.
Main Methods:
- Silicene nanosheet-modified decalcified bone matrix (SNS@DBM) scaffold fabrication.
- Molecular dynamics simulations to elucidate collagen-silicene interactions.
- In vivo studies in tumor-bearing nude mice and critical defect rats.
Main Results:
- SNS@DBM demonstrated tunable photothermal properties for sequential thermotherapy.
- The scaffold achieved simultaneous residual tumor ablation, recurrence prevention, and bone regeneration in vivo.
- Moderate heat stimulation upregulated osteogenic genes, promoted M2 macrophage polarization, and enhanced angiogenesis.
Conclusions:
- SNS@DBM offers a versatile, integrated approach for managing tumorous bone defects.
- The
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