Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Computed Tomography01:10

Computed Tomography

4.4K
Tomography refers to imaging by sections. Computed tomography (CT) is a non-invasive imaging technique that uses computers to analyze several cross-sectional X-rays to reveal minute details about structures in the body.
The technique was invented in the 1970s and is based on the principle that as X-rays pass through the body, they are absorbed or reflected at different levels. In the technique, a patient lies on a motorized platform while a computerized axial tomography (CAT) scanner rotates...
4.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cytomorphologic Predictors of Adenoid Cystic Carcinoma: Insights From a Multi-Center Logistic Regression Study.

Diagnostic cytopathology·2026
Same author

Clinical and histologic features of a novel polyostotic proliferative bone disease in lovebirds (Agapornis spp).

Journal of the American Veterinary Medical Association·2026
Same author

Intracranial mesenchymal tumor, FET::CREB fusion-positive: An integrative analysis of 81 cases.

Neuro-oncology·2026
Same author

Assessing Vocational Rehabilitation Agency Capacity to Engage in Evidence-Based Decision Making.

Journal of vocational rehabilitation·2025
Same author

American College of Radiology Thyroid Imaging Reporting System and cytopathologic classification: integration for improved assessment of malignancy risk.

Journal of the American Society of Cytopathology·2025
Same author

Defining "Paradoxical Instability" and Other Indications for Aseptic Single-Component Polyethylene Revision: A Cohort Study Including Mid-flexion Instability and Limited Arc of Motion.

Arthroplasty today·2025
Same journal

Assessing Human Epidermal Growth Factor Receptor 2 in Urothelial Carcinoma: Insights From Clinical Practice Into Scoring Criteria, Histologic Subtypes, and Genomic Characteristics Across Disease Sites.

Archives of pathology & laboratory medicine·2026
Same journal

Cross-Reactivity of TPIT Antibody Clone OTI2G1 in Chordoma: Structural Mechanisms and Diagnostic Implications.

Archives of pathology & laboratory medicine·2026
Same journal

Paracoccidioidomycosis at Autopsy: A Case Series and Literature Review.

Archives of pathology & laboratory medicine·2026
Same journal

Accuracy of Cytology Diagnosis for Well Differentiated Neuroendocrine Tumors: Assessment by the College of American Pathologists Non-Gynecologic Slide Program.

Archives of pathology & laboratory medicine·2026
Same journal

Serum Immunofixation Electrophoresis Guidance Conflict: A Call to Harmonize.

Archives of pathology & laboratory medicine·2026
Same journal

In Reply.

Archives of pathology & laboratory medicine·2026
See all related articles

Related Experiment Video

Updated: Jun 20, 2025

Computed Tomography and Optical Imaging of Osteogenesis-angiogenesis Coupling to Assess Integration of Cranial Bone Autografts and Allografts
13:16

Computed Tomography and Optical Imaging of Osteogenesis-angiogenesis Coupling to Assess Integration of Cranial Bone Autografts and Allografts

Published on: December 22, 2015

11.4K

Finding Missing Calcifications: How Deep to Cut?

Lester J Layfield1, Magda Esebua1, Meghan White1

  • 1From the Department of Pathology and Anatomical Sciences, University of Missouri, Columbia (Layfield, Esebua, White).

Archives of Pathology & Laboratory Medicine
|July 22, 2024
PubMed
Summary
This summary is machine-generated.

A six-level cutting protocol is optimal for detecting microcalcifications in breast biopsies. This approach ensures accurate histologic sampling, improving the identification of breast pathology markers.

More Related Videos

Identifying Coronary Artery Calcification on Non-gated Computed Tomography Scans
04:40

Identifying Coronary Artery Calcification on Non-gated Computed Tomography Scans

Published on: August 28, 2018

15.2K
Author Spotlight: Enhanced Quantification of Cardiovascular Calcification Progression for Longitudinal Micro PET/CT Studies in Small Research Animals
08:02

Author Spotlight: Enhanced Quantification of Cardiovascular Calcification Progression for Longitudinal Micro PET/CT Studies in Small Research Animals

Published on: November 15, 2024

581

Related Experiment Videos

Last Updated: Jun 20, 2025

Computed Tomography and Optical Imaging of Osteogenesis-angiogenesis Coupling to Assess Integration of Cranial Bone Autografts and Allografts
13:16

Computed Tomography and Optical Imaging of Osteogenesis-angiogenesis Coupling to Assess Integration of Cranial Bone Autografts and Allografts

Published on: December 22, 2015

11.4K
Identifying Coronary Artery Calcification on Non-gated Computed Tomography Scans
04:40

Identifying Coronary Artery Calcification on Non-gated Computed Tomography Scans

Published on: August 28, 2018

15.2K
Author Spotlight: Enhanced Quantification of Cardiovascular Calcification Progression for Longitudinal Micro PET/CT Studies in Small Research Animals
08:02

Author Spotlight: Enhanced Quantification of Cardiovascular Calcification Progression for Longitudinal Micro PET/CT Studies in Small Research Animals

Published on: November 15, 2024

581

Area of Science:

  • Pathology
  • Radiology
  • Histology

Background:

  • Mammographic microcalcifications often indicate breast pathology and may necessitate biopsy.
  • Inadequate histologic sampling can lead to missed diagnoses when microcalcifications are absent in initial tissue sections.

Purpose of the Study:

  • To determine the optimal cutting protocol for identifying mammary microcalcifications in breast biopsies.
  • To enhance the accuracy of histologic examination for suspected microcalcifications.

Main Methods:

  • Retrospective review of 431 surgical pathology records for cases with mammographically identified microcalcifications (January 2022 - March 2023).
  • Analysis of the level at which microcalcifications were first detected in retrieved slides.
  • Evaluation of standard and extended cutting protocols.

Main Results:

  • Microcalcifications were present in 415 of 431 (96.3%) evaluated specimens.
  • The probability of detecting microcalcifications in the initial section was 62.9%.
  • Histologic detection rates reached 90.5% within the first 4 levels and 97% within the first 6 levels.

Conclusions:

  • A 6-level cutting protocol is optimal for detecting microcalcifications in breast biopsies.
  • This optimized sampling strategy can improve diagnostic accuracy for suspected lesions.
  • The findings may inform protocols for other specimen types requiring deep tissue examination.