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Published on: February 16, 2024
Ulcerative Colitis or Not? A Case of Dysplasia, Gastrointestinal Bleeding, and Juvenile Polyposis in a 27-Year-Old
Tianyu She1, Stephanie Ren1, Harry He2
1Department of Medicine, New York University Langone Long Island, New York, NY.
Insights
Juvenile polyposis syndrome, a hamartomatous condition, presents a cancer risk. In a rare case, it co-occurred with ulcerative colitis, complicating diagnosis and treatment for this 27-year-old patient.
Area of Science:
- Gastroenterology and Oncology
Background:
- Juvenile polyposis syndrome (JPS) is a hamartomatous polyposis syndrome associated with increased risks of colorectal and gastric cancers.
- Ulcerative colitis (UC) is a chronic inflammatory bowel disease that also increases the risk of colorectal cancer.
Abstract:
Juvenile polyposis syndrome lies within the family of hamartomatous polyposis syndromes characterized by polyps that appear benign but harbor an increased risk of colorectal and gastric cancer. This 27-year-old man with severe ulcerative colitis was discovered to have concomitant juvenile polyposis syndrome during diagnostic workup for gastrointestinal bleeding. The implications of this rare association complicate both diagnostic and treatment modalities since both diseases confer an increased risk of cancer.
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