Glucagon-like immunoreactivity in mouse and rat retina

Mouse and rat retinae were examined by the peroxidase-anti-peroxidase technique of immunocytochemistry using an antiserum against glucagon. The immunoreactivity was found in the cells of the ganglion cell layer and inner nuclear layer, including Müller cells. These observations may indicate that glucagon or a similar peptide is important in neuromodulation and/or metabolism of retinal cells.