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Related Concept Videos

Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
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Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...

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Combining QD-FRET and Microfluidics to Monitor DNA Nanocomplex Self-Assembly in Real-Time
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Supramolecular Modulator Assisted Cryo-Engineered Porous Cu-DNA Nano-Vehicles for Versatile Theranostic Agent

Cui Ren1, Fang Wang2, Xiaoyi Meng1

  • 1Department of Chemistry, School of Science, Tianjin University, Tianjin, 300072, China.

Advanced Healthcare Materials
|July 22, 2024
PubMed
Summary

Researchers developed a universal DNA nanocarrier using pore engineering for enhanced drug delivery. This scalable platform enables customized cancer therapy by efficiently loading diverse theranostic agents.

Keywords:
DNA nano‐vehicledrug deliveryporous nanoparticlesupramolecular mediationtumor theranostics

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Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Chemical Engineering

Background:

  • DNA nanotechnology offers programmable therapeutic functions but struggles with drug loading capacity.
  • Current drug carriers face complex synthesis and compatibility issues when switching cargo.

Purpose of the Study:

  • To engineer a universal, highly porous DNA nanocarrier for diverse theranostic agent loading.
  • To overcome the limitations of existing drug delivery systems through a novel pore-engineering strategy.

Main Methods:

  • Coordination self-assembly of copper ions (Cu2+) and G3139 nucleic acid therapeutic.
  • Cryo-engineering and sublimation to create porosity in the nanostructure, forming porous Cu-G3139 nanoparticles (CG NPs).
  • Loading of diverse therapeutic molecules, including chemotherapeutics and photosensitizers like indocyanine green (ICG), facilitated by cyclodextrin.

Main Results:

  • Demonstrated efficient loading of various therapeutic molecules into porous CG NPs.
  • Developed a proof-of-concept CICG@TA nanocarrier for synergistic tumor ablation via photothermal therapy and fluorescence imaging.
  • Achieved sublimation-induced pore formation in metal-DNA hybrid nanoparticles without chemical etching.

Conclusions:

  • Introduced a scalable, "plug-and-play" platform for personalized cancer therapy.
  • Established a versatile pore-engineering strategy merging supramolecular chemistry and cryo-engineered porosity.
  • Opened new avenues for efficient, customized multidrug delivery in tumor theranostics.