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Related Experiment Videos

[Polycenter evaluation of the break-point system].

P Casella, R Vaiani, M R Sala

    Quaderni Sclavo Di Diagnostica Clinica E Di Laboratorio
    |March 1, 1985
    PubMed
    Summary

    The Sensititre break-point system shows high agreement with traditional methods for microbial sensitivity testing, with minor discrepancies mainly linked to cephalotin efficacy in E. coli.

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    Area of Science:

    • Microbiology
    • Clinical Diagnostics
    • Antimicrobial Susceptibility Testing

    Background:

    • Evaluating microbial sensitivity is crucial for effective treatment.
    • Traditional methods like agar diffusion (Bauer et al.) are established standards.
    • The Sensititre break-point system offers a potentially faster alternative.

    Purpose of the Study:

    • To assess the accuracy and efficiency of the Sensititre break-point system.
    • To compare Sensititre break-point results with agar diffusion and Sensititre MIC.
    • To evaluate the time and cost-effectiveness of the Sensititre break-point method.

    Main Methods:

    • Comparison of Sensititre break-point with agar diffusion using 1180 Gram-negative bacterial strains.
    • Comparison of Sensititre break-point with Sensititre MIC using 176 strains.

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  • Analysis of 448 strains tested with correct and simplified inoculums.
  • Time and cost analysis of the break-point functioning.

    • Main Results:

    • Overall agreement between Sensititre break-point and Bauer system was 90.3%, with 2% major disagreement.
    • Major disagreement between Sensititre MIC and break-point was 2.7%, primarily due to cephalotin and E. coli.
    • Break-point tests are faster (10 min vs. 18 min) and cheaper (4500 Lit vs. 5600 Lit).

    Conclusions:

    • The Sensititre break-point system demonstrates good concordance with established methods.
    • Discrepancies, particularly with cephalotin on E. coli, warrant further investigation.
    • The Sensititre break-point system offers significant time and cost advantages.