Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Neuron Structure01:31

Neuron Structure

222.3K
Overview
222.3K
Nervous Tissue: Neuron Types01:19

Nervous Tissue: Neuron Types

2.7K
Neurons, the fundamental units of the nervous system, can be classified based on both their structural and functional characteristics.
Structurally, neurons are categorized into three main types: multipolar, bipolar, and unipolar (or pseudounipolar). Multipolar neurons, which are the most common type in the brain and spinal cord, as well as all motor neurons, possess multiple dendrites and a single axon.
Bipolar neurons, on the other hand, have one primary dendrite and one axon. They are...
2.7K
Neural Circuits01:25

Neural Circuits

1.1K
Neural circuits and neuronal pools are two of the main structures found in the nervous system. Neural circuits are networks of neurons that work together to carry out a specific task or process. They consist of interconnected neurons and glial cells, which provide structural and metabolic support.
Neuronal pools are collections of nerve cells with similar functions and interact through chemical and electrical signals. These pools include both interneurons (the central neural circuit nodes that...
1.1K
Neuronal Communication01:28

Neuronal Communication

823
Neurons, the fundamental units of the brain and nervous system, communicate through complex electrochemical signals that underpin all cognitive and bodily functions. This communication is primarily facilitated by a process involving the generation and propagation of an action potential along the axon of the neuron. When the internal electrical charge of a neuron surpasses a certain threshold, an action potential is triggered. This rapid change in voltage travels swiftly along the axon to the...
823
The Role of Ion Channels in Neuronal Computation01:19

The Role of Ion Channels in Neuronal Computation

3.2K
A postsynaptic neuron usually receives numerous impulses from several other presynaptic neurons. The axon hillock of the postsynaptic neuron integrates all these signals and determines the likelihood of firing an action potential.
Sometimes a single EPSP is strong enough to induce an action potential in the postsynaptic neuron. However, multiple presynaptic inputs must often create EPSPs around the same time for the postsynaptic neuron to be sufficiently depolarized to fire an action potential....
3.2K
Neurons: The Cell Body and the Dendrites01:23

Neurons: The Cell Body and the Dendrites

2.9K
A typical nerve cell comprises three main components: the cell body, dendrites, and the axon. The cell body, also known as the soma or perikaryon, serves as the central biosynthetic hub housing a nucleus surrounded by cytoplasm containing organelles commonly found in most cells. Notably, Nissl bodies, clusters of the rough endoplasmic reticulum and free ribosomes responsible for protein synthesis, are distinctive features of the neuronal cell body. As neurons age, aggregates of a brown pigment...
2.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cognitive function depends upon <i>Satb2</i> gene dosage in cortical projection neurons.

bioRxiv : the preprint server for biology·2026
Same author

Feature-specific threat coding in lateral septum guides defensive action.

Nature·2026
Same author

Pyramidal neurons proportionately alter cortical interneuron subtypes.

Nature·2026
Same author

Non-reciprocal callosal projections and input gradients underlie interhemispheric communication in binocular visual cortex.

Cell reports·2026
Same author

Discrete interneuron subsets participate in GluN1/GluN3A excitatory glycine receptor (eGlyR)-mediated regulation of hippocampal network activity throughout development and evolution.

Research square·2025
Same author

Discrete interneuron subsets participate in GluN1/GluN3A excitatory glycine receptor (eGlyR)-mediated regulation of hippocampal network activity throughout development and evolution.

bioRxiv : the preprint server for biology·2025
Same journal

Evolutionary and Biochemical Perspectives on the Incorporation and Utilization of Selenocysteine.

Cold Spring Harbor perspectives in biology·2026
Same journal

The Mitochondrial Calcium Uniporter: From Parts to Signaling Networks.

Cold Spring Harbor perspectives in biology·2026
Same journal

Growth Control and Beyond: Functional Diversity and Regulation of the Hippo Pathway in the Nervous System.

Cold Spring Harbor perspectives in biology·2026
Same journal

Structural Studies of Core Hippo Pathway Components.

Cold Spring Harbor perspectives in biology·2026
Same journal

The Hippo Pathway in Intestinal Regeneration, Fetal Reprogramming, and Tumorigenesis.

Cold Spring Harbor perspectives in biology·2026
Same journal

A Synergy between Genetics and Biochemistry Unravels the Molecular Architecture of the Hippo Signaling Pathway.

Cold Spring Harbor perspectives in biology·2026
See all related articles

Related Experiment Video

Updated: Jun 20, 2025

Homochronic Transplantation of Interneuron Precursors into Early Postnatal Mouse Brains
10:08

Homochronic Transplantation of Interneuron Precursors into Early Postnatal Mouse Brains

Published on: June 8, 2018

7.9K

Interneuron Diversity: How Form Becomes Function.

Natalia V De Marco García1, Gord Fishell2,3

  • 1Center for Neurogenetics, Brain and Mind Research Institute, Weill Cornell Medicine, New York, New York 10021, USA nad2018@med.cornell.edu gordon_fishell@hms.harvard.edu.

Cold Spring Harbor Perspectives in Biology
|July 22, 2024
PubMed
Summary
This summary is machine-generated.

Neuroscience research explores how neuronal subtype identity forms during circuit development. This study reveals transient interneuron identities are crucial for circuit assembly, consolidating into adult subtypes as transient connections are eliminated.

More Related Videos

Biocytin Recovery and 3D Reconstructions of Filled Hippocampal CA2 Interneurons
11:21

Biocytin Recovery and 3D Reconstructions of Filled Hippocampal CA2 Interneurons

Published on: November 20, 2018

8.5K
Design, Surface Treatment, Cellular Plating, and Culturing of Modular Neuronal Networks Composed of Functionally Inter-connected Circuits
10:32

Design, Surface Treatment, Cellular Plating, and Culturing of Modular Neuronal Networks Composed of Functionally Inter-connected Circuits

Published on: April 15, 2015

8.5K

Related Experiment Videos

Last Updated: Jun 20, 2025

Homochronic Transplantation of Interneuron Precursors into Early Postnatal Mouse Brains
10:08

Homochronic Transplantation of Interneuron Precursors into Early Postnatal Mouse Brains

Published on: June 8, 2018

7.9K
Biocytin Recovery and 3D Reconstructions of Filled Hippocampal CA2 Interneurons
11:21

Biocytin Recovery and 3D Reconstructions of Filled Hippocampal CA2 Interneurons

Published on: November 20, 2018

8.5K
Design, Surface Treatment, Cellular Plating, and Culturing of Modular Neuronal Networks Composed of Functionally Inter-connected Circuits
10:32

Design, Surface Treatment, Cellular Plating, and Culturing of Modular Neuronal Networks Composed of Functionally Inter-connected Circuits

Published on: April 15, 2015

8.5K

Area of Science:

  • Neuroscience
  • Developmental Neuroscience
  • Computational Neuroscience

Background:

  • Establishing neuronal subtype identity during circuit development remains a key neuroscience question.
  • Transcriptomic data on cortical interneurons is advancing, yet mechanisms of identity acquisition and functional relevance are unclear.
  • Interneuron identity is thought to arise from a combination of intrinsic genetic programs and activity-dependent processes.

Purpose of the Study:

  • To investigate how progressive interactions between interneurons and pyramidal cells influence the acquisition of transient neuronal identities.
  • To understand the role of these transient identities in neuronal circuit assembly and function.
  • To elucidate how the elimination of transient connectivity leads to the consolidation of stable, adult neuronal subtypes.

Main Methods:

  • Focus on developmental interactions between interneurons and pyramidal cells.
  • Analysis of transient neuronal identities during circuit assembly.
  • Investigation of the role of transient connectivity elimination in subtype consolidation.

Main Results:

  • Identified transient identities in maturing interneurons, essential for their function during circuit assembly.
  • Demonstrated that progressive interactions with pyramidal cells are critical for establishing these transient identities.
  • Showed that the elimination of transient connectivity is a key trigger for the consolidation of adult interneuron subtypes.

Conclusions:

  • Transient neuronal identities, shaped by interneuron-pyramidal cell interactions, are fundamental for functional circuit assembly.
  • The dynamic process of connection elimination and consolidation refines neuronal identity, leading to mature subtypes.
  • This work provides insights into the developmental mechanisms underlying neuronal diversity and circuit function.