Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Circadian Rhythms and Gene Regulation02:19

Circadian Rhythms and Gene Regulation

4.0K
The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent...
4.0K
Factors Affecting Body Temperature01:28

Factors Affecting Body Temperature

4.0K
As a nurse, it is vital to understand the factors affecting body temperature to monitor variations and effectively evaluate deviations from regular.
Factors may  include:
4.0K
Body Temperature01:07

Body Temperature

286
Body temperature reflects the equilibrium between heat production and heat loss within the body. Most heat is generated by metabolically active tissues, particularly the liver, heart, brain, kidneys, and endocrine organs. At rest, skeletal muscles contribute 20–30% of total heat production, but during vigorous exercise, this can increase up to 30–40 times.
The average body temperature is approximately 37°C (98.6°F) and typically ranges from 36.1–37.2°C...
286
Metabolic Rate01:25

Metabolic Rate

320
The human body is a powerhouse of energy, with every cell performing numerous functions that require energy. This energy production and consumption is measured by the metabolic rate, which quantifies the total heat generated by all the body's chemical reactions and mechanical work. This measurement helps to determine the rate of kilocalorie (kcal) consumption needed to fuel all ongoing activities.
The Basal Metabolic Rate (BMR) measures the energy expended at rest.
Several factors influence...
320
Thermoregulation01:26

Thermoregulation

947
The human body has a sophisticated thermoregulation system that employs negative feedback mechanisms to maintain an optimal core temperature. When the core temperature drops, peripheral and central thermoreceptors send signals to the hypothalamus, activating the heat-promoting center. This center triggers several responses aimed at increasing the core temperature. First, vasoconstriction reduces the flow of warm blood from internal organs to the skin so that the heat is not lost from the skin,...
947
Requirements for Human Life01:26

Requirements for Human Life

8.1K
The Earth and its atmosphere have provided humans with air, water, and food, but these are not the only requirements for survival. Humans also require a specific range of temperature and pressure that the Earth and its atmosphere provides.
Oxygen
Atmospheric air is only about 20 percent oxygen, but that oxygen is a key component of the chemical reactions that keep the body alive, including the reactions that produce ATP. Brain cells are susceptible to a lack of oxygen because they require a...
8.1K
  1. Home
  3. Higher Central Circadian Temperature Amplitude Is Associated With Greater Metabolite Rhythmicity In Humans.
  1. Home
  3. Higher Central Circadian Temperature Amplitude Is Associated With Greater Metabolite Rhythmicity In Humans.

Related Experiment Video

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures
06:53

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures

Published on: November 11, 2016

8.3K

Higher central circadian temperature amplitude is associated with greater metabolite rhythmicity in humans.

Daniel P Windred1,2, Clare Anderson3,4, Katherine J Jeppe3,5

  • 1Flinders Health and Medical Research Institute (Sleep Health), Flinders University, Bedford Park, SA, Australia. daniel.windred@flinders.edu.au.

Scientific Reports
|July 22, 2024

View abstract on PubMed

Summary
This summary is machine-generated.

A stronger core body temperature rhythm indicates a more organized circadian system in humans. This suggests that body temperature rhythms can reveal the robustness of the central circadian clock.

Keywords:
Biological rhythmsCircadian clockCircadian organizationCore body temperaturePeripheral oscillators

More Related Videos

Human Circadian Phenotyping and Diurnal Performance Testing in the Real World
10:16

Human Circadian Phenotyping and Diurnal Performance Testing in the Real World

Published on: April 7, 2020

8.5K
In Vitro Bioluminescence Assay to Characterize Circadian Rhythm in Mammary Epithelial Cells
11:56

In Vitro Bioluminescence Assay to Characterize Circadian Rhythm in Mammary Epithelial Cells

Published on: September 28, 2017

9.7K

Related Experiment Videos

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures
06:53

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures

Published on: November 11, 2016

8.3K
Human Circadian Phenotyping and Diurnal Performance Testing in the Real World
10:16

Human Circadian Phenotyping and Diurnal Performance Testing in the Real World

Published on: April 7, 2020

8.5K
In Vitro Bioluminescence Assay to Characterize Circadian Rhythm in Mammary Epithelial Cells
11:56

In Vitro Bioluminescence Assay to Characterize Circadian Rhythm in Mammary Epithelial Cells

Published on: September 28, 2017

9.7K

Area of Science:

  • Chronobiology
  • Metabolomics
  • Human Physiology

Background:

  • Robust circadian rhythms are vital for health.
  • The central circadian clock regulates body temperature rhythms, which organize peripheral rhythms in rodents.
  • The relationship between human temperature rhythms and peripheral circadian organization remains unclear.

Purpose of the Study:

  • To investigate if core body temperature amplitude and rhythmicity correlate with the organization of circadian rhythms of blood plasma metabolites in humans.
  • To determine if a stronger central circadian clock, indicated by temperature rhythms, is associated with better peripheral circadian organization.

Main Methods:

  • Assessed core body temperature amplitude and the rhythmicity of 929 blood plasma metabolites.
  • Utilized a 40-hour constant routine protocol in 23 healthy individuals.
  • Controlled for behavioral and environmental factors that can mask endogenous rhythms.

    • Main Results:

    • Higher core body temperature amplitude was linked to a greater number of metabolites showing circadian rhythms (R²=0.37, p=0.009).
    • Increased core body temperature amplitude correlated with reduced variability in metabolite rhythm periods (R²=0.47, p=0.002).
    • These findings suggest a link between temperature rhythm robustness and metabolite rhythm organization.

    Conclusions:

    • A robust central circadian clock in humans is associated with better organization of circadian metabolite rhythms.
    • Metabolite rhythms may serve as a valuable indicator of central circadian clock strength.
    • This research provides insights into human circadian system organization and its relation to core body temperature.