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Updated: Jun 20, 2025
Genome-Wide Analysis of DNA Methylation in Gastrointestinal Cancer
Published on: September 18, 2020
Potential diagnostic, prognostic, and predictive biomarkers of gastric cancer
Ousman Mohammed1, Solomon Tebeje Gizaw2, Maria Degef2
1Department of Medical Laboratory Sciences College of Medicine and Health Sciences, Wollo University Dessie Ethiopia.
Background:
Gastric cancer (GC), a malignant epithelial tumor, is the fourth leading cause of cancer-related death worldwide. Therapeutic strategies for GC, despite the biggest challenges, can significantly improve survival rates through early detection and effective screening methods.
Aim:
To provide brief information on the necessity of multiple specific diagnostic, prognostic, and predictive markers for GC.
Methods:
This review was conducted using a variety of search engines, including PubMed Central, Scopus, Web of Science, Google Scholar, and others.
Results:
Some potential biomarkers that provide essential information include circulating tumor cells (CTCs), DNA methylation, claudin 18.2, fibroblast growth factor receptor 2 (FGFR2), long noncoding RNAs (lncRNAs), cell-free DNA (cfDNA), microRNAs, and serum pepsinogens.
Conclusion:
Multiple tumor markers are essential for screening, tumor identification, staging, prognostic assessment, and monitoring recurrence after therapy due to the absence of a single tumor indicator for diagnosing, prognosticating, and predicting GC.
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