[Variability in the intensity of albumin synthesis in mouse hepatocytes]

Using immunoenzyme method followed by the cytophotometrical determination of individual protein content in single cells, a comparative analysis was made of albumin contents in hepatocytes of inbred mouse stocks significantly differing in their albumin contents in the blood. Some reasons of heterogeneity of parenchymal liver cells in respect to albumin synthesis were identified. The content of albumin in hepatocytes was shown to correlate with the cell ploidy. A probable contribution of the tissue level to gene expression control is discussed.