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Related Concept Videos

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Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
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Updated: Jun 20, 2025

Rapid Generation of Amyloid from Native Proteins In vitro
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Exploring pathological link between antimicrobial and amyloid peptides.

Yijing Tang1, Yanxian Zhang2, Dong Zhang3

  • 1Department of Chemical, Biomolecular, and Corrosion Engineering, The University of Akron, Ohio 44325, USA. zhengj@uakron.edu.

Chemical Society Reviews
|July 23, 2024
PubMed
Summary
This summary is machine-generated.

Amyloid peptides (AMYs) and antimicrobial peptides (AMPs) share structural traits, enabling cross-talk in neurodegenerative diseases and infections. Understanding this interplay may yield novel therapies for both conditions.

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Area of Science:

  • Biochemistry
  • Molecular Biology
  • Pathology

Background:

  • Amyloid peptides (AMYs) and antimicrobial peptides (AMPs) are distinct peptide families.
  • Emerging evidence links AMYs and AMPs in neurodegenerative diseases and microbial infections.
  • Shared structural and functional characteristics exist between AMYs and AMPs.

Purpose of the Study:

  • To review recent developments in the interplay between AMYs and AMPs.
  • To examine the pathological implications of AMY-AMP interactions in disease.
  • To highlight challenges and inspire future research in this field.

Main Methods:

  • Literature review of existing studies on AMY-AMP interactions.
  • Analysis of shared structural and functional properties.
  • Discussion of cross-seeding phenomena and bidirectional communication.

Main Results:

  • AMYs can exhibit antimicrobial activity, and AMPs can display amyloidogenic properties.
  • Cross-seeding between AMYs and AMPs is a key factor in disease pathogenesis.
  • The interplay influences both neurodegeneration and host defense mechanisms.

Conclusions:

  • The molecular crosstalk between AMYs and AMPs is crucial in infectious and neurodegenerative diseases.
  • Further research is needed to fully understand these interactions.
  • This knowledge can lead to innovative therapeutic strategies for multiple disorders.