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Updated: Jun 20, 2025

Versatile CO2 Transformations into Complex Products: A One-pot Two-step Strategy
Published on: November 9, 2019
Scalable organocatalytic one pot asymmetric Strecker reaction via camphor sulfonyl functionalized
Apoorva Malik1, Kirti Antil1, Nikhil Singh1
1Sustainable Materials and Catalysis Research Laboratory (SMCRL), Department of Chemistry, Indian Institute of Technology Jodhpur, Jodhpur-342037, India. pragati@iitj.ac.in.
Abstract:
In this communication, we designed a highly selective camphor sulfonyl functionalized crown-ether-tethered calix[4]arene-derived organocatalyst for asymmetric Strecker reaction to provide the desired cyano adducts in high yields (∼99.9% yield) and enantioselectivities (up to 99.3% ee). Furthermore, 2 step facile syntheses of the antiplatelet drug (S)-clopidogrel exemplify the potential of this method for the preparation of commercial compounds.
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