Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Disorders of the Male Reproductive System01:20

Disorders of the Male Reproductive System

377
Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
377
Adrenal Gland Disorders01:27

Adrenal Gland Disorders

1.5K
Adrenal gland disorders manifest when the production of adrenal hormones deviates from the norm, resulting in either excessive or insufficient concentrations.
Adrenal insufficiency, characterized by insufficient cortisol and aldosterone production, leads to conditions like Addison's disease. This disorder, affecting the adrenal cortex, exhibits symptoms such as skin bronzing, dehydration, low blood pressure, fatigue, and weight loss. Congenital adrenal hyperplasia, a genetic ailment causing...
1.5K
Menopause01:28

Menopause

149
Menopause, a natural biological process marking the end of a woman's fertility, typically occurs between the fifth and sixth decade of life. This phase is characterized by the exhaustion of the ovarian follicle pool, leading to less responsive ovaries despite the high levels of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). The consequential decrease in estrogen production results in symptoms like hot flashes, heavy sweating, headaches, hair loss, muscle pains, vaginal...
149
Testosterone: Functions and Regulation01:26

Testosterone: Functions and Regulation

604
The intricate hormonal interplay essential for male reproductive health begins with the release of gonadotropin-releasing hormone (GnRH) by the hypothalamus. This hormone prompts the pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). LH targets the Leydig cells in the testes, stimulating them to produce and release testosterone. In concert with testosterone, FSH acts on the Sertoli cells within the seminiferous tubules to facilitate the release of...
604
Signs of Puberty01:27

Signs of Puberty

303
Puberty is a critical phase, typically beginning between the ages of 8 and 13 in girls and 9 and 14 in boys, though timing can vary based on genetics, environmental factors, and overall health. This period is characterized by the development of secondary sexual characteristics and the attainment of reproductive potential. Endocrine changes underpin puberty, with hormonal surges of Luteinizing Hormone (LH) and Follicle-Stimulating Hormone (FSH) instigated by Gonadotropin-Releasing Hormone (GnRH)...
303
Infertility in Males01:23

Infertility in Males

256
Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...
256

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Testosterone Therapy After Radical Prostatectomy: Insights From a Systematic Review and Meta-Analysis.

Andrology·2026
Same author

Ultrasound localisation microscopy tracks testicular microvascular adaptations to endocrine function in male infertility.

EBioMedicine·2026
Same author

A comparative evaluation of on-demand phosphodiesterase-5 inhibitor efficacy in erectile dysfunction treatment: a systematic review and network meta-analysis of double-blind, placebo-controlled, randomized trials.

The journal of sexual medicine·2026
Same author

Correction: Penile prosthesis implantation: a systematic review of intraoperative and postoperative complications.

International journal of impotence research·2026
Same author

EAU Guidelines on Sexual and Reproductive Health: A Summary of the 2026 Recommendations for Measurement and Biochemical Confirmation of Hypogonadism.

European urology focus·2026
Same author

The effectiveness of hormonal treatment to improve reproductive outcomes in normo-gonadotropic men with abnormal semen parameters: Results of two linked systematic reviews.

The Journal of clinical endocrinology and metabolism·2026

Related Experiment Video

Updated: Jun 20, 2025

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
07:25

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

Published on: March 6, 2018

13.0K

Androgen abuse: Risks and adverse effects in men.

Bonnie Grant1, Elizabeth Hyams1, Rhianna Davies1

  • 1Section of Investigative Medicine, Imperial College London, London, UK.

Annals of the New York Academy of Sciences
|July 23, 2024
PubMed
Summary

Androgen abuse, including anabolic-androgenic steroids, poses serious health risks like cardiovascular issues and mental disorders, even years after stopping. Clinicians must recognize and manage these harms.

Keywords:
anabolic‐androgenic steroidsandrogen abuseperformance enhancementtestosterone

More Related Videos

Murine Prostate Micro-dissection and Surgical Castration
08:49

Murine Prostate Micro-dissection and Surgical Castration

Published on: May 11, 2016

45.5K
Establishment of Rat Models Mimicking Gender-affirming Hormone Therapies
06:27

Establishment of Rat Models Mimicking Gender-affirming Hormone Therapies

Published on: January 10, 2025

712

Related Experiment Videos

Last Updated: Jun 20, 2025

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
07:25

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

Published on: March 6, 2018

13.0K
Murine Prostate Micro-dissection and Surgical Castration
08:49

Murine Prostate Micro-dissection and Surgical Castration

Published on: May 11, 2016

45.5K
Establishment of Rat Models Mimicking Gender-affirming Hormone Therapies
06:27

Establishment of Rat Models Mimicking Gender-affirming Hormone Therapies

Published on: January 10, 2025

712

Area of Science:

  • Endocrinology
  • Toxicology
  • Men's Health

Background:

  • Androgens, or anabolic-androgenic steroids, are increasingly abused for nonmedical performance enhancement.
  • Abuse is linked to significant mortality and multisystem adverse effects, including cardiovascular, hepatic, and mental health issues.
  • Negative health consequences can persist long after cessation, and disclosure is often reluctant due to black market sourcing.

Purpose of the Study:

  • To summarize the adverse effects and risks associated with androgen abuse in men.
  • To raise awareness among clinicians regarding the prevalence and harms of androgen abuse.

Main Methods:

  • This is a narrative review.
  • The review synthesizes existing literature on androgen abuse and its consequences.

Main Results:

  • Androgen abuse is associated with increased mortality.
  • Reported adverse effects include cardiovascular toxicity, infertility, hypogonadism, hepatotoxicity, and mental health disorders.
  • Long-term health consequences and challenges in managing substance dependence and relapse are significant.

Conclusions:

  • Clinicians across specialties need awareness of androgen abuse, its prevalence, and its detrimental effects on men and their families.
  • Management of adverse effects is complex, requiring organ-specific approaches and addressing physical, neuropsychiatric, and dependence issues.
  • Encouraging cessation of androgen abuse is crucial for mitigating long-term health risks.