Local-Regional Therapy for Oligometastatic Colorectal Cancer.

Area of Science:

• Oncology
• Gastroenterology
• Surgical Oncology

Background:

• Colorectal cancer (CRC) is a leading cause of cancer death in the US.
• Over 30% of CRC patients develop metastatic disease, primarily to the liver and lungs.
• Untreated metastatic CRC has a poor prognosis.

Purpose of the Study:

• To review the evidence for local therapies in treating oligometastatic colorectal cancer.
• To discuss the expanding role of local treatments for patients ineligible for surgery.

Main Methods:

• Literature review of thermal ablation techniques.
• Review of hepatic artery infusions.
• Examination of chemoembolization and radioembolization evidence.
• Analysis of stereotactic ablative radiation therapy data.

Main Results:

• Local therapies are expanding treatment options for metastatic CRC.
• Evidence supports various modalities for liver and lung metastases.
• Patient selection for local therapy is crucial for long-term survival.

Conclusions:

• Innovations in local therapies are improving outcomes for oligometastatic CRC.
• Thermal ablation, infusions, embolization, and radiation offer alternatives to surgery.
• Further research is needed to optimize treatment strategies for metastatic CRC.