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Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells
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Long non-coding RNAs; potential contributors in cancer chemoresistance through modulating diverse molecular

Hashem O Alsaab1, Mohammad S Alzahrani2, Atheer F Alaqile3

  • 1Department of Pharmaceutics and Pharmaceutical Technology, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia.

Pathology, Research and Practice
|July 23, 2024
PubMed

Insights

Long non-coding RNAs (lncRNAs) significantly influence cancer drug resistance by regulating gene expression. Understanding lncRNA roles is crucial for developing new cancer therapies targeting chemoresistance.

Area of Science:

  • Molecular Biology
  • Oncology
  • Genetics

Background:

  • Chemotherapy is a cornerstone of cancer treatment, but drug resistance remains a major cause of treatment failure.
  • Long non-coding RNAs (lncRNAs) are key regulators of gene expression, impacting various cancer hallmarks including drug resistance.

Purpose of the Study:

  • To provide an in-depth analysis of the recently discovered functions of lncRNAs in cancer pathogenesis and chemoresistance.
  • To highlight the crucial roles lncRNAs play in the development of drug resistance.

Main Methods:

  • Literature review and analysis of existing studies on lncRNA-driven mechanisms of chemoresistance.
  • Identification of lncRNAs involved in various cancer hallmarks and their association with drug resistance.

Main Results:

  • LncRNAs influence multiple cancer hallmarks, including DNA damage, metastasis, and cell stemness, all of which contribute to drug resistance.
  • Diverse drug resistance mechanisms are associated with specific lncRNAs, indicating their multifaceted roles.
  • Several lncRNAs have emerged as potential biomarkers and therapeutic targets for cancer treatment.

Conclusions:

  • LncRNAs are critical players in cancer chemoresistance, influencing its development and progression.
  • Targeting lncRNAs presents a promising strategy for overcoming drug resistance in cancer therapies.
  • Further research into lncRNA functions can pave the way for novel drug resistance-conquering strategies.
Keywords:
CancerDrug resistancelong non-coding RNAs (lncRNAs)

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