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Multiparametric Optical Mapping of the Langendorff-perfused Rabbit Heart
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Preparation-based B   1 + mapping in the heart using Bloch-Siegert shifts.

Paulina Šiurytė1, Joao Tourais1, Yi Zhang1

  • 1Department of Imaging Physics, Delft University of Technology, Delft, The Netherlands.

Magnetic Resonance in Medicine
|July 24, 2024
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Summary

This study introduces a new Bloch-Siegert shift (BSS)-based cardiac mapping technique for 3 Tesla MRI. The method offers robust, tailorable 2D/3D cardiac T1 mapping in a single breath-hold, improving scan efficiency and data quality.

Keywords:
BBloch–Siegert shiftcardiac imagingpreparation‐based

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Area of Science:

  • Cardiovascular Magnetic Resonance Imaging (CMR)
  • Quantitative MRI
  • Biophysical Modeling

Background:

  • Accurate cardiac T1 mapping is crucial for diagnosing and monitoring various cardiovascular diseases.
  • Existing T1 mapping techniques at 3 Tesla (3T) face challenges with robustness, scan time, and sensitivity.
  • Bloch-Siegert shift (BSS) offers a potential mechanism for improving MRI sequence performance.

Purpose of the Study:

  • To develop and validate a novel cardiac T1 mapping sequence utilizing Bloch-Siegert shift (BSS)-based preparations.
  • To evaluate the robustness, accuracy, and efficiency of the developed BSS-based sequence at 3T.
  • To assess the feasibility of both 2D and 3D whole-heart T1 mapping within a single breath-hold.

Main Methods:

  • A longitudinal magnetization preparation module was designed to encode T1 information using BSS.
  • Bloch simulations were employed to optimize pulse parameters and assess mapping sensitivity and relaxation-induced errors.
  • Phantom and healthy subject studies were conducted to evaluate mapping range, repeatability, and consistency, comparing with conventional BSS and HS8 methods. 3D acquisition was also assessed.

Main Results:

  • The BSS-based preparation demonstrated high mapping sensitivity, particularly at higher T1 ranges.
  • The technique achieved a 20-fold reduction in standard deviation for repeated scans compared to conventional BSS and showed improved repeatability over the HS8 method.
  • Robust cardiac T1 maps were acquired with low test-retest variability and plane intersection bias. 3D acquisitions showed good agreement with 2D scans.

Conclusions:

  • Bloch-Siegert shift-based preparations provide a robust and adaptable method for cardiac T1 mapping at 3T.
  • The developed sequence enables efficient 2D and 3D whole-heart T1 mapping within a single breath-hold.
  • This technique holds promise for improved diagnostic accuracy and workflow efficiency in cardiovascular MRI.