Considerations for applying emerging technologies in paediatric laboratory medicine

Area of Science:

• Paediatric Laboratory Medicine
• Clinical Diagnostics
• Emerging Technologies

Background:

• Paediatric laboratory medicine is a recent specialization recognizing children's unique physiological needs.
• Emerging technologies, including novel biomarkers and devices, have the potential to significantly improve clinical diagnostics.

Purpose of the Study:

• To summarize key takeaways on applying emerging technologies in paediatric laboratory medicine.
• To discuss critical considerations for implementing these technologies in pediatric settings.

Main Methods:

• Illustrative examples from four clinical areas: neonatal hypoglycaemia, neonatal hyperbilirubinaemia, sickle cell disorder, and congenital adrenal hyperplasia.
• Exploration of six technological advancements: microassays, noninvasive testing, alternative matrices, next-generation sequencing, exosome analysis, and machine learning.

Main Results:

• Summarized applications of emerging technologies across selected paediatric clinical scenarios.
• Identified nine key considerations for the successful integration of emerging technologies in paediatric laboratory medicine.

Conclusions:

• Emerging technologies hold significant promise for advancing paediatric diagnostics.
• Careful consideration of implementation factors is crucial for realizing the full potential of these innovations in child healthcare.