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Updated: Jun 19, 2025

Conditional Reprogramming of Pediatric Human Esophageal Epithelial Cells for Use in Tissue Engineering and Disease Investigation
Published on: March 22, 2017
Esophageal replacement in children - 27 years of experience in a University Hospital
Flavia Garcia Frogeri1, Joaquim Bustorff-Silva1, Antonio Gonçalves DE Oliveira Filho1
1- Unicamp, Cirurgia Pediátrica - Campinas - SP - Brasil.
Insights
Pediatric esophageal replacement using gastric transposition or esophagocoloplasty has high morbidity but allows oral feeding. Proximal fistulas are common but usually resolve spontaneously, guiding individualized surgical technique selection.
Area of Science:
- Pediatric Surgery
- Gastroenterology
- Thoracic Surgery
Background:
- Esophageal replacement is necessary in children with conditions like esophageal atresia and caustic stenosis.
- This study reviews two esophageal replacement techniques used in a university hospital setting.
Purpose of the Study:
- To report the experience and outcomes of two esophageal replacement techniques in pediatric patients.
- To compare the efficacy and complications of gastric transposition and esophagocoloplasty.
Main Methods:
- Retrospective review of hospital records for patients undergoing esophageal replacement between 1995 and 2022.
- Analysis of patient demographics, underlying diseases, surgical techniques, complications, and long-term results.
Main Results:
- Thirty pediatric patients underwent esophageal replacement; 73.33% had esophageal atresia and 26.67% had caustic stenosis.
- Gastric transposition was performed in 70% and esophagocoloplasty in 30% of patients.
- The most frequent complication was proximal anastomotic fistula (14 patients), typically resolving spontaneously; three deaths occurred.
Conclusions:
- Esophageal replacement in children is associated with significant morbidity and mortality.
- Gastric transposition and esophagocoloplasty demonstrate similar outcomes, with proximal fistulas being more common in esophagocoloplasty but generally self-resolving.
- Individualized patient and surgeon factors should guide the choice between gastric transposition and esophagocoloplasty to achieve oral feeding ability.
Introduction:
esophageal replacement in children is indicated when it is impossible to maintain the native esophagus, which in the pediatric population includes patients with esophageal atresia and esophageal caustic stenosis. The objective of this communication is to report the experience of a university service with two techniques of esophageal replacement.
Methods:
this is a retrospective study based on the revision of hospital files. The study population consisted of patients who underwent esophageal replacement from 1995 to 2022, at the Hospital de Clínicas of the State University of Campinas. The analyzed data were age, sex, underlying disease, technical aspects, complications, and long-term results.
Results:
during the study period, 30 patients underwent esophageal replacement. The most common underlying diseases were esophageal atresia (73.33%) and caustic stenosis (26.67%). Twenty-one patients underwent gastric transposition (70%), and nine underwent esophagocoloplasty (30%). The most frequent postoperative complication was fistula of the proximal anastomosis, which occurred in 14 patients. Most of the patients with fistulas had a spontaneous recovery. There were three deaths. Of the 27 survivors, 24 can feed exclusively by mouth.
Conclusion:
esophageal replacement in children is a procedure with high morbidity and mortality. Esophagocoloplasty and gastric transposition have similar results and complications, with the exception of proximal anastomotic fistulas, which are generally self-resolving and are more common in esophagocoloplasty. The choice of the best surgical technique must be individualized according to the patients characteristics and the surgeons experience, as both techniques offer the ability to feed orally in the short or medium term.
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