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Related Concept Videos

Drugs for Treatment of Constipation-Predominant IBS01:21

Drugs for Treatment of Constipation-Predominant IBS

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Pharmacological therapies for IBS-C are designed to alleviate abdominal discomfort and enhance bowel function. In patients with IBS-C, fiber supplements may help soften stools and decrease straining, but may also lead to increased gas production and bloating. Osmotic laxatives like milk of magnesia are frequently used to soften stools and increase stool frequency in IBS-C patients. In addition, two drugs approved for use in severe IBS-C adult cases are linaclotide (Linzess) and lubiprostone...
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Laxatives are primarily used to alleviate constipation, a common gastrointestinal disorder characterized by infrequent bowel movements and difficulty passing stools. They work by various mechanisms to increase the volume or frequency of bowel movements. The primary modes of action of laxatives include increasing stool bulk, softening the stool, stimulating intestinal motility, and osmotically drawing water into the intestines.
Osmotic or saline laxatives, like magnesium hydroxide or milk of...
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Drugs Affecting GI Tract Motility: Serotonin Receptor Agonists01:23

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Serotonin, a crucial neurotransmitter synthesized by enterochromaffin cells, plays a cardinal role in regulating gastrointestinal (GI) motility. With over 90% of the body's total serotonin in the GI tract, its influence on digestive processes is profound. Serotonin is swiftly released upon various stimuli, such as food boluses or certain drugs, triggering intrinsic sensory neurons in the myenteric plexus and extrinsic vagal and spinal sensory neurons. This leads to the activation of the...
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Drugs Affecting GI Tract Motility: Bulk-Forming and Stimulant Laxatives01:22

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Laxatives enhance bowel movements and alleviate constipation. They augment the stool's bulk, stimulate intestinal muscle contractions, draw water into the intestines, or soften the stool. There are five key types of laxatives: bulk laxatives, stimulant laxatives, osmotic laxatives, stool softeners, and lubricant laxatives.
Bulk-forming laxatives, such as psyllium, methylcellulose, and polycarbophil, absorb water in the intestine, increasing stool bulk and promoting bowel movement. This...
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Drugs for Treatment of Diarrhea-Predominant IBS01:17

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Diarrhea-predominant irritable bowel syndrome (IBS-D) is a subtype of IBS characterized primarily by frequent, loose, or watery stools, abdominal pain, and abdominal discomfort. Therapeutic approaches to managing IBS-D include dietary changes, stress management techniques, and pharmaceutical interventions.
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Imaging Studies III: Gastrointestinal Motility Studies and Virtual Colonoscopy01:26

Imaging Studies III: Gastrointestinal Motility Studies and Virtual Colonoscopy

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This lesson explores three gastrointestinal imaging techniques: radionuclide testing, colonic transit studies, and virtual colonoscopy.
Radionuclide Testing
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Updated: Jun 19, 2025

Electroacupuncture Combined with Chinese Medicine Ironing Therapy for Functional Constipation
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EFFECT OF VISCERAL MANIPULATION ON CHILDREN WITH REFRACTORY CHRONIC FUNCTIONAL CONSTIPATION: A RANDOMIZED CONTROLLED

Seyed Arman Zakaryaei1, Majid Ravanbakhsh2,3, Hazhir Javaherizadeh4

  • 1Student Research Committee, School of Rehabiliatation Sciences, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Arquivos De Gastroenterologia
|July 24, 2024
PubMed
Summary
This summary is machine-generated.

Visceral manipulation (VM) offers a safe, effective complementary treatment for children with chronic functional constipation (FC) unresponsive to standard care. This approach significantly improved symptoms and reduced laxative dependence in a randomized controlled trial.

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Area of Science:

  • Pediatric Gastroenterology
  • Manual Therapy
  • Clinical Trial Research

Background:

  • Functional constipation (FC) is a prevalent global health issue affecting children.
  • Refractory FC cases often require alternative therapeutic strategies beyond standard medical care.

Purpose of the Study:

  • To assess the efficacy of visceral manipulation (VM) as an adjunct therapy for pediatric chronic functional constipation (FC).
  • To evaluate VM's impact on children with FC refractory to standard treatments.

Main Methods:

  • A randomized, single-blind controlled trial involving 52 children with refractory FC.
  • Participants received either standard medical care (SMC) or SMC plus VM for 4 weeks.
  • Outcomes included abdominal pain, defecation pain, stool consistency, frequency, and laxative dose.

Main Results:

  • The VM group showed significant improvements in pain, defecation, and stool consistency compared to controls.
  • Oral laxative dosage significantly decreased in the VM group but not in the control group.
  • While overall Bristol stool form scale scores didn't differ significantly between groups, normal stool consistency increased in the VM group.

Conclusions:

  • Visceral manipulation (VM) is a safe and effective complementary treatment for managing chronic functional constipation (FC) in children.
  • VM, alongside standard medical care, offers a promising therapeutic option with no reported side effects.
  • Further research is warranted to explore the long-term effects of VM in pediatric FC management.