Related Experiment Video
Updated: Jun 19, 2025
Combining Peripheral Nerve Grafting and Matrix Modulation to Repair the Injured Rat Spinal Cord
Published on: November 20, 2009
End-to-side neurorrhaphy in the reconstruction of peripheral segmental neural loss: an experimental study
Rafael Silva Lemos1, Livia Guerreiro de Barros Bentes1, Maria Eduarda Dos Santos Lopes Vasconcelos2
1Universidade do Estado do Pará - Faculdade de Medicina - Laboratório de Cirurgia Experimental - Belém (PA) - Brazil.
Purpose:
To evaluate the effects on peripheral neural regeneration of the end-to-side embracing repair technique compared to the autograft repair technique in Wistar rats.
Methods:
Fifteen male Wistar rats were divided into three groups with five animals each: denervated group (GD), autograft group (GA), and embracing group (EG). For the evaluation, the grasping test, electroneuromyography (ENMG), and muscle weight assessment were used.
Results:
Muscle weight assessment and ENMG did not show significant neural regeneration at the end of 12 weeks in the DG and GE groups, but only in GA. The grasping test showed an increase in strength between the surgery and the fourth week in all groups, and only the GA maintained this trend until the 12th week.
Conclusions:
The present study indicates that the neural regeneration observed in the end-to-side embracing neurorrhaphy technique, in the repair of segmental neural loss, is inferior to autograft repair in Wistar rats.
