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Incidence and Prevalence of Early-Onset Dementia in Finland
Johanna Krüger1, Mikko Aaltonen1, Kalle Aho1
1From the Research Unit of Clinical Medicine (J.K., A.L., L.L., I.R., L.T., N.-M.S.), Neurology, University of Oulu; MRC (J.K., L.T., N.-M.S.); Neurocenter (J.K., L.T., N.-M.S.), Neurology, Oulu University Hospital; Law School (M.A., A.M.-P.-L.), University of Eastern Finland, Joensuu; Institute of Clinical Medicine - Neurology (K.A., S.H., A.K., H.S., K.K., E.S.); A.I. Virtanen Institute for Molecular Sciences (A.H.), University of Eastern Finland, Kuopio; Clinical Neurosciences (A.M.P.), Faculty of Medicine, University of Helsinki; and Neuro Center - Neurology (P.H., E.S.), Kuopio University Hospital, Finland.
Objectives:
Current epidemiologic data of early-onset dementia (EOD), characterized by the onset of the disease before the age of 65, are notably scarce.
Methods:
We evaluated the incidence (from January 2010 to December 2021) and prevalence (on December 31, 2021) of EOD and its subtypes in 2 defined areas in Finland. All visits at the dementia outpatient clinics were manually retrospectively reviewed and reassessed (N = 12,490).
Results:
In the population aged ≤65 years, crude incidence of EOD was 12.3/100,000 persons at risk/year based on 794 new cases from January 1, 2010, to December 31, 2021. Incidence rates for EOD were 20.5 and 33.7 per 100,000 person years in the age group of 30-64 and 45-64 years, respectively. The prevalence of EOD was 110.4 in the age group of 30-64 years and 190.3 in the age group 45-64. Alzheimer disease (AD) (48.2%) and behavioral variant frontotemporal dementia (12.7%) were the most frequent subtypes. The incidence of AD increased during the follow-up, whereas incidence of other forms of EOD remained stable.
Discussion:
We found higher incidence rates of EOD than previously reported. Unlike other forms of EOD, the incidence of early-onset AD seems to be increasing.
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